Design, antihuman immunodeficiency activity and molecular docking studies of synthesized 2-aryl and 2-pyrimidinyl pyrrolidines

Author:

Gasparyan Sahak P.ORCID,Martirosyan Ashot H.,Alexanyan Marina V.,Harutyunyan Gohar K.,Chilingaryan Garri V.,Coats Steve,Schinazi Raymond F.

Funder

Civilian Research and Development Foundation

NIH

Publisher

Springer Science and Business Media LLC

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Drug Discovery,Molecular Biology,General Medicine,Information Systems,Catalysis

Reference23 articles.

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2. De Corte BL (2005) From 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk](1,4)benzodiazepin-2(1H)-one (TIBO) to Etravirine (TMC125): fifteen years of research on non-nucleoside inhibitors of HIV-1 reverse transcriptase. J Med Chem 48:1689–1696. https://doi.org/10.1021/jm040127p

3. Pauwels R, Andries K, Debyser Z, Van Daele P, Schols D, Stoffels P, De Vreese K, Woestenborghs R, Vandamme AM, Janssen CGM, Anne J, Cauwenbergh G, Desmyter J, Heykants J, Janssen MAC, De Clercq E, Janssen PAJ (1993) Potent and highly selective human immunodeficiency virus type 1 (HIV-1) inhibition by a series of a-anilinophenylacetamide derivatives targeted at HIV-1 reverse transcriptase. Proc Natl Acad Sci USA 90:1711–1715. https://doi.org/10.1073/pnas.90.5.1711

4. Schinazi RF, Sommadossi JP, Saalmann V, Cannon DL, Xie M-W, Hart GC, Smith GA, Hahn EF (1990) Activities of 3′-azido-3′-deoxythymidine nucleotide dimers in primary lymphocytes infected with human immunodeficiency virus type 1. Antimicrob Agents Chemother 34(6):1061–1067. https://doi.org/10.1128/aac.34.6.1061

5. Stuyver LJ, Lostia S, Adams M, Mathew J, Pai BS, Grier J, Tharnish P, Choi Y, Chong Y, Choo H, Chu CK, Otto MJ, Schinazi RF (2002) Antiviral activities and cellular toxicities of modified 2′,3′-dideoxy-2′,3′-didehydrocytidine analogues. Antimicrob Agents Chemother 46(12):3854–3860. https://doi.org/10.1128/AAC.46.12.3854-3860.2002

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