Formation of bis-spiropyrrolidines from isatin, secondary amines, and alkylidene Meldrum’s acids
Author:
Publisher
Springer Science and Business Media LLC
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Drug Discovery,Molecular Biology,General Medicine,Information Systems,Catalysis
Link
https://link.springer.com/content/pdf/10.1007/s11030-023-10610-0.pdf
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2. Zheng Y, Tice CM, Singh SB (2014) The use of spirocyclic scaffolds in drug discovery. Bioorg Med Chem Lett 24:3673–3682. https://doi.org/10.1016/j.bmcl.2014.06.081
3. Babu TH, Joseph AA, Muralidharan D, Perumal PT (2010) A novel method for the synthesis of functionalized spirocyclic oxindoles by one-pot tandem reaction of vinyl malononitriles with isatylidene malononitriles. Tetrahedron Lett 51:994–996. https://doi.org/10.1016/j.tetlet.2009.12.082
4. Cao ZY, Zhou F, Zhou J (2018) Development of synthetic methodologies via catalytic enantioselective synthesis of 3,3-disubstituted oxindoles. Acc Chem Res 51:1443–1454. https://doi.org/10.1021/acs.accounts.8b00097
5. Ziarani GM, Moradi R, Lashgari N (2015) Asymmetric synthesis of chiral 3,3-disubstituted oxindoles using Isatin as starting material. Tetrahedron Asymmetry 26:517–541. https://doi.org/10.1016/j.tet.2018.01.025
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