Pharmacokinetics and metabolism of tomoxiprole, a new analgesic antiinflammatory agent, in the rat

Author:

Assandri A.,Bernareggi A.,Ripamonti A.,Perazzi A.,Toja E.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology

Reference7 articles.

1. Toja E., Selva D., and Schiatti P. (1984): 3-Alkyl-2-aryl-3H-naphth (1,2-d) imidazoles, a novel class of non-acidic antiinflammatory agents. J. Med. Chem.,27, 610–616.

2. Schiatti P., Selva D., Galliani G., Baldoli E., Toja E. and Glässer A. (1985): Highly selective antiinflammatory and analgesic activity of 3-(1-methyl-ethyl)-2-(4-methoxyphenyl)-3H-naphth(1,2-d)imidazole (tomoxiprole), a new non-acidic molecule. Arzneimittel Forsch. Drug. Res. (in press).

3. Luzzani F., Colombo G., Schiatti P., Selva D. and Glässer A. (1984): Inhibition of PG-production by tomoxiprole, a new steroidal non acidic antiinflammatory compound in rat gastric mucosa a n d inflammatory exudate. IRCS Med. Sei.,12, 77–78.

4. Odasso G. and Toja E. (1983): One pot synthesis of 3-(1-methylethyl)-2-(4-methoxyphenyl)-3H-naphth-(1,2-d) imidazole. J. Lab. and Radiopharm.,20, 1189–1192.

5. Bernareggi A., Ratti B. and Toselli A. (1984): High-performance liquid chromatography of MDL-035 in the plasma of rats, dogs and humans. J. Liquid Chrom.,7, 2093–2101.

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