Health-related conditions among long-term cancer survivors diagnosed in adolescence and young adulthood (AYA): results of the SURVAYA study

Author:

Janssen Silvie H. M.ORCID,Vlooswijk CarlaORCID,Bijlsma Rhodé M.ORCID,Kaal Suzanne E. J.ORCID,Kerst Jan Martijn,Tromp Jacqueline M.,Bos Monique E. M. M.ORCID,van der Hulle TomORCID,Lalisang Roy I.ORCID,Nuver JanineORCID,Kouwenhoven Mathilde C. M.ORCID,van der Graaf Winette T. A.ORCID,Husson OlgaORCID

Abstract

Abstract Background With 5-year survival rates > 85%, gaining insight into the long-term and late health-related conditions of cancer survivors diagnosed in adolescence and young adulthood is of utmost importance to improve their quantity and quality of survival. This study examined the prevalence of and factors associated with, patient-reported health-related conditions and their latency times among long-term adolescent and young adult (AYA) cancer survivors. Methods AYA cancer survivors (5–20 years after diagnosis) were identified by the population-based Netherlands Cancer Registry (NCR), and invited to participate in the SURVAYA questionnaire study. Participants reported the prevalence and date of diagnosis of health-related conditions. Clinical data were retrieved from the NCR. Results Three thousand seven hundred seventy-six AYA cancer survivors (response rate 33.4%) were included for analyses. More than half of the AYAs (58.5%) experienced health-related conditions after their cancer diagnosis, of whom 51.4% were diagnosed with two or more conditions. Participants reported conditions related to vision (15.0%), digestive system (15.0%), endocrine system (14.1%), cardiovascular system (11.7%), respiratory system (11.3%), urinary tract system (10.9%), depression (8.6%), hearing (7.4%), arthrosis (6.9%), secondary malignancy (6.4%), speech-, taste and smell (4.5%), and rheumatoid arthritis (2.1%). Time since diagnosis, tumor type, age at diagnosis, and educational level were most frequently associated with a health-related condition. Conclusions A significant proportion of long-term AYA cancer survivors report having one or more health-related conditions. Implications for cancer survivors Future research should focus on better understanding the underlying mechanisms of, and risk factors for, these health-related conditions to support the development and implementation of risk-stratified survivorship care for AYA cancer survivors to further improve their outcomes. Clinical trials registration NCT05379387.

Funder

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

KWF Kankerbestrijding

Publisher

Springer Science and Business Media LLC

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