Highly mutated monoclonal antibody 3F2 targets a conformational and strain-restricted epitope in human immunodeficiency virus gp41 with significant antibody-dependent cell cytotoxicity-Reference-Cited by-同舟云学术

Highly mutated monoclonal antibody 3F2 targets a conformational and strain-restricted epitope in human immunodeficiency virus gp41 with significant antibody-dependent cell cytotoxicity

Published:2022-07-24 Issue:11 Volume:167 Page:2193-2201
ISSN:0304-8608
Container-title:Archives of Virology
language:en
Short-container-title:Arch Virol

Author:

DeCotes Devin,Baron Sarah,Hoffman Jonathon,Garrett Meghan,Sojar Hakimuddin,Hicar Mark D.^ORCID

Funder

National Institute of Allergy and Infectious Diseases

Publisher

Springer Science and Business Media LLC

Subject

Virology,General Medicine

Link

https://link.springer.com/content/pdf/10.1007/s00705-022-05518-3.pdf

Reference28 articles.

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2. Hicar MD, Chen X, Sulli C, Barnes T, Goodman J, Sojar H, Briney B, Willis J, Chukwuma VU, Kalams SA, Doranz BJ, Spearman P, Crowe JE Jr (2016) Human antibodies that recognize novel immunodominant quaternary epitopes on the HIV-1 env protein. PLoS One. 11:e0158861. https://doi.org/10.1371/journal.pone.0158861

3. Hicar MD, Chen X, Kalams SA, Sojar H, Landucci G, Forthal DN, Spearman P, Crowe JE Jr (2016) Low frequency of broadly neutralizing HIV antibodies during chronic infection even in quaternary epitope targeting antibodies containing large numbers of somatic mutations. Mol Immunol. 70:94–103. https://doi.org/10.1016/j.molimm.2015.12.002

4. Sojar H, Baron S, Sullivan JT, Garrett M, Van Haaren MM, Hoffman J, Overbaugh J, Doranz BJ, Hicar MD (2019) Monoclonal antibody 2C6 targets a cross-clade conformational epitope in gp41 with highly active antibody-dependent cell cytotoxicity. J Virol. https://doi.org/10.1128/JVI.00772-19

5. Haynes BF, Gilbert PB, Mcelrath MJ, Zolla-Pazner S, Tomaras GD, Alam SM, Evans DT, Montefiori DC, Karnasuta C, Sutthent R, Liao HX, Devico AL, Lewis GK, Williams C, Pinter A, Fong Y, Janes H, Decamp A, Huang Y, Rao M, Billings E, Karasavvas N, Robb ML, Ngauy V, De Souza MS, Paris R, Ferrari G, Bailer RT, Soderberg KA, Andrews C, Berman PW, Frahm N, De Rosa SC, Alpert MD, Yates NL, Shen X, Koup RA, Pitisuttithum P, Kaewkungwal J, Nitayaphan S, Rerks-Ngarm S, Michael NL, Kim JH (2012) Immune-correlates analysis of an HIV-1 vaccine efficacy trial. N Engl J Med. 366:1275–86. https://doi.org/10.1056/NEJMoa1113425

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