Mechanisms of phototherapy of Alzheimer’s disease during sleep and wakefulness: the role of the meningeal lymphatics
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Published:2023-09-18
Issue:1
Volume:16
Page:
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ISSN:2095-2767
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Container-title:Frontiers of Optoelectronics
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language:en
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Short-container-title:Front. Optoelectron.
Author:
Oxana Semyachkina-Glushkovskaya,Alexander Shirokov,Inna Blokhina,Ivan Fedosov,Andrey Terskov,Alexander Dubrovsky,Maria Tsoy,Daria Elovenko,Viktoria Adushkina,Arina Evsukova,Valeria Telnova,Anna Tzven,Valeria Krupnova,Maria Manzhaeva,Alexander Dmitrenko,Thomas Penzel,Jürgen Kurths
Abstract
AbstractWith the increase in the aging population, the global number of people with Alzheimer’s disease (AD) progressively increased worldwide. The situation is aggravated by the fact that there is no the effective pharmacological therapy of AD. Photobiomodulation (PBM) is non-pharmacological approach that has shown very promising results in the therapy of AD in pilot clinical and animal studies. However, the mechanisms of therapeutic effects of PBM for AD are poorly understood. In this study on mice, we demonstrate that photodynamic effects of 5-aminolevulenic acid and laser 635 nm cause reduction of network of the meningeal lymphatic vessels (MLVs) leading to suppression of lymphatic removal of beta-amyloid (Aβ) from the right lateral ventricle and the hippocampus. Using the original protocol of PBM under electroencephalographic monitoring of wakefulness and sleep stages in non-anesthetized mice, we discover that the 7-day course of PBM during deep sleep vs. wakefulness provides better restoration of clearance of Aβ from the ventricular system of the brain and the hippocampus. Our results shed light on the mechanism of PBM and show the stimulating effects of PBM on the brain lymphatic drainage that promotes transport of Aβ via the lymphatic pathway. The effects of PBM on the brain lymphatics in sleeping brain open a new niche in the study of restorative functions of sleep as well as it is an important informative platform for the development of innovative smart sleep technologies for the therapy of AD.
Graphical Abstract
Publisher
Springer Science and Business Media LLC
Subject
Electrical and Electronic Engineering,Electronic, Optical and Magnetic Materials
Reference68 articles.
1. Li, X., Feng, X., Sun, X., Hou, N., Han, F., Liu, Y.: Global, regional, and national burden of Alzheimer’s disease and other dementias, 1990–2019. Front. Aging Neurosci. 14, 937486 (2022) 2. Murray, C.J.L., Aravkin, A.Y., Zheng, P., Abbafati, C., Abbas, K.M., Abbasi-Kangevari, M., Abd-Allah, F., Abdelalim, A., Abdollahi, M., Abdollahpour, I., Abegaz, K.H., Abolhassani, H., Aboyans, V., Abreu, L.G., Abrigo, M.R.M., Abualhasan, A., Abu-Raddad, L.J., Abushouk, A.I., Adabi, M., Adekanmbi, V., Adeoye, A.M., Adetokunboh, O.O., Adham, D., Advani, S.M., Agarwal, G., Aghamir, S.M.K., Agrawal, A., Ahmad, T., Ahmadi, K., Ahmadi, M., Ahmadieh, H., Ahmed, M.B., Akalu, T.Y., Akinyemi, R.O., Akinyemiju, T., Akombi, B., Akunna, C.J., Alahdab, F., Al-Aly, Z., Alam, K., Alam, S., Alam, T., Alanezi, F.M., Alanzi, T.M., Alemu, B., Alhabib, K.F., Ali, M., Ali, S., Alicandro, G., Alinia, C., Alipour, V., Alizade, H., Aljunid, S.M., Alla, F., Allebeck, P., Almasi-Hashiani, A., Al-Mekhlafi, H.M., Alonso, J., Altirkawi, K.A., Amini-Rarani, M., Amiri, F., Amugsi, D.A., Ancuceanu, R., Anderlini, D., Anderson, J.A., Andrei, C.L., Andrei, T., Angus, C., Anjomshoa, M., Ansari, F., Ansari-Moghaddam, A., Antonazzo, I.C., Antonio, C.A.T., Antony, C.M., Antriyandarti, E., Anvari, D., Anwer, R., Appiah, S.C.Y., Arabloo, J., Arab-Zozani, M., Ariani, F., Armoon, B., Ärnlöv, J., Arzani, A., Asadi-Aliabadi, M., Asadi-Pooya, A.A., Ashbaugh, C., Assmus, M., Atafar, Z., Atnafu, D.D., Atout, M.M.W., Ausloos, F., Ausloos, M., Ayala Quintanilla, B.P., Ayano, G., Ayanore, M.A., Azari, S., Azarian, G., Azene, Z.N., Badawi, A., Badiye, A.D., Bahrami, M.A., Bakhshaei, M.H., Bakhtiari, A., Bakkannavar, S.M., Baldasseroni, A., Ball, K., Ballew, S.H., Balzi, D., Banach, M., Banerjee, S.K., Bante, A.B., Baraki, A.G., Barker-Collo, S.L., Bärnighausen, T.W., Barrero, L.H., Barthelemy, C.M., Barua, L., Basu, S., Baune, B.T., Bayati, M., Becker, J.S., Bedi, N., Beghi, E., Béjot, Y., Bell, M.L., Bennitt, F.B., Bensenor, I.M., Berhe, K., Berman, A.E., Bhagavathula, A.S., Bhageerathy, R., Bhala, N., Bhandari, D., Bhattacharyya, K., Bhutta, Z.A., Bijani, A., Bikbov, B., Bin Sayeed, M.S., Biondi, A., Birihane, B.M., Bisignano, C., Biswas, R.K., Bitew, H., Bohlouli, S., Bohluli, M., Boon-Dooley, A.S., Borges, G., Borzì, A.M., Borzouei, S., Bosetti, C., Boufous, S., Braithwaite, D., Breitborde, N.J.K., Breitner, S., Brenner, H., Briant, P.S., Briko, A.N., Briko, N.I., Britton, G.B., Bryazka, D., Bumgarner, B.R., Burkart, K., Burnett, R.T., Burugina Nagaraja, S., Butt, Z.A., Caetano dos Santos, F.L., Cahill, L.E., Cámera, L.L.A.A., Campos-Nonato, I.R., Cárdenas, R., Carreras, G., Carrero, J.J., Carvalho, F., Castaldelli-Maia, J.M., Castañeda-Orjuela, C.A., Castelpietra, G., Castro, F., Causey, K., Cederroth, C.R., Cercy, K.M., Cerin, E., Chandan, J.S., Chang, K.L., Charlson, F.J., Chattu, V.K., Chaturvedi, S., Cherbuin, N., Chimed-Ochir, O., Cho, D.Y., Choi, J.Y.J., Christensen, H., Chu, D.T., Chung, M.T., Chung, S.C., Cicuttini, F.M., Ciobanu, L.G., Cirillo, M., Classen, T.K.D., Cohen, A.J., Compton, K., Cooper, O.R., Costa, V.M., Cousin, E., Cowden, R.G., Cross, D.H., Cruz, J.A., Dahlawi, S.M.A., Damasceno, A.A.M., Damiani, G., Dandona, L., Dandona, R., Dangel, W.J., Danielsson, A.K., Dargan, P.I., Darwesh, A.M., Daryani, A., Das, J.K., Das Gupta, R., das Neves, J., Dávila-Cervantes, C.A., Davitoiu, D.V., De Leo, D., Degenhardt, L., DeLang, M., Dellavalle, R.P., Demeke, F.M., Demoz, G.T., Demsie, D.G., Denova-Gutiérrez, E., Dervenis, N., Dhungana, G.P., Dianatinasab, M., Dias da Silva, D., Diaz, D., Dibaji Forooshani, Z.S., Djalalinia, S., Do, H.T., Dokova, K., Dorostkar, F., Doshmangir, L., Driscoll, T.R., Duncan, B.B., Duraes, A.R., Eagan, A.W., Edvardsson, D., El Nahas, N., El Sayed, I., El Tantawi, M., Elbarazi, I., Elgendy, I.Y., El-Jaafary, S.I., Elyazar, I.R.F., Emmons-Bell, S., Erskine, H.E., Eskandarieh, S., Esmaeilnejad, S., Esteghamati, A., Estep, K., Etemadi, A., Etisso, A.E., Fanzo, J., Farahmand, M., Fareed, M., Faridnia, R., Farioli, A., Faro, A., Faruque, M., Farzadfar, F., Fattahi, N., Fazlzadeh, M., Feigin, V.L., Feldman, R., Fereshtehnejad, S.M., Fernandes, E., Ferrara, G., Ferrari, A.J., Ferreira, M.L., Filip, I., Fischer, F., Fisher, J.L., Flor, L.S., Foigt, N.A., Folayan, M.O., Fomenkov, A.A., Force, L.M., Foroutan, M., Franklin, R.C., Freitas, M., Fu, W., Fukumoto, T., Furtado, J.M., Gad, M.M., Gakidou, E., Gallus, S., Garcia-Basteiro, A.L., Gardner, W.M., Geberemariyam, B.S., Gebreslassie, A.A.A.A., Geremew, A., Gershberg Hayoon, A., Gething, P.W., Ghadimi, M., Ghadiri, K., Ghaffarifar, F., Ghafourifard, M., Ghamari, F., Ghashghaee, A., Ghiasvand, H., Ghith, N., Gholamian, A., Ghosh, R., Gill, P.S., Ginindza, T.G.G., Giussani, G., Gnedovskaya, E.V., Goharinezhad, S., Gopalani, S.V., Gorini, G., Goudarzi, H., Goulart, A.C., Greaves, F., Grivna, M., Grosso, G., Gubari, M.I.M., Gugnani, H.C., Guimarães, R.A., Guled, R.A., Guo, G., Guo, Y., Gupta, R., Gupta, T., Haddock, B., Hafezi-Nejad, N., Hafiz, A., Haj-Mirzaian, A., Haj-Mirzaian, A., Hall, B.J., Halvaei, I., Hamadeh, R.R., Hamidi, S., Hammer, M.S., Hankey, G.J., Haririan, H., Haro, J.M., Hasaballah, A.I., Hasan, M.M., Hasanpoor, E., Hashi, A., Hassanipour, S., Hassankhani, H., Havmoeller, R.J., Hay, S.I., Hayat, K., Heidari, G., Heidari-Soureshjani, R., Henrikson, H.J., Herbert, M.E., Herteliu, C., Heydarpour, F., Hird, T.R., Hoek, H.W., Holla, R., Hoogar, P., Hosgood, H.D., Hossain, N., Hosseini, M., Hosseinzadeh, M., Hostiuc, M., Hostiuc, S., Househ, M., Hsairi, M., Hsieh, V.C., Hu, G., Hu, K., Huda, T.M., Humayun, A., Huynh, C.K., Hwang, B.F., Iannucci, V.C., Ibitoye, S.E., Ikeda, N., Ikuta, K.S., Ilesanmi, O.S., Ilic, I.M., Ilic, M.D., Inbaraj, L.R., Ippolito, H., Iqbal, U., Irvani, S.S.N., Irvine, C.M.S., Islam, M.M., Islam, S.M.S., Iso, H., Ivers, R.Q., Iwu, C.C.D., Iwu, C.J., Iyamu, I.O., Jaafari, J., Jacobsen, K.H., Jafari, H., Jafarinia, M., Jahani, M.A., Jakovljevic, M., Jalilian, F., James, S.L., Janjani, H., Javaheri, T., Javidnia, J., Jeemon, P., Jenabi, E., Jha, R.P., Jha, V., Ji, J.S., Johansson, L., John, O., John-Akinola, Y.O., Johnson, C.O., Jonas, J.B., Joukar, F., Jozwiak, J.J., Jürisson, M., Kabir, A., Kabir, Z., Kalani, H., Kalani, R., Kalankesh, L.R., Kalhor, R., Kanchan, T., Kapoor, N., Karami Matin, B., Karch, A., Karim, M.A., Kassa, G.M., Katikireddi, S.V., Kayode, G.A., Kazemi Karyani, A., Keiyoro, P.N., Keller, C., Kemmer, L., Kendrick, P.J., Khalid, N., Khammarnia, M., Khan, E.A., Khan, M., Khatab, K., Khater, M.M., Khatib, M.N., Khayamzadeh, M., Khazaei, S., Kieling, C., Kim, Y.J., Kimokoti, R.W., Kisa, A., Kisa, S., Kivimäki, M., Knibbs, L.D., Knudsen, A.K.S., Kocarnik, J.M., Kochhar, S., Kopec, J.A., Korshunov, V.A., Koul, P.A., Koyanagi, A., Kraemer, M.U.G., Krishan, K., Krohn, K.J., Kromhout, H., Kuate Defo, B., Kumar, G.A., Kumar, V., Kurmi, O.P., Kusuma, D., La Vecchia, C., Lacey, B., Lal, D.K., Lalloo, R., Lallukka, T., Lami, F.H., Landires, I., Lang, J.J., Langan, S.M., Larsson, A.O., Lasrado, S., Lauriola, P., Lazarus, J.V., Lee, P.H., Lee, S.W.H., LeGrand, K.E., Leigh, J., Leonardi, M., Lescinsky, H., Leung, J., Levi, M., Li, S., Lim, L.L., Linn, S., Liu, S., Liu, S., Liu, Y., Lo, J., Lopez, A.D., Lopez, J.C.F., Lopukhov, P.D., Lorkowski, S., Lotufo, P.A., Lu, A., Lugo, A., Maddison, E.R., Mahasha, P.W., Mahdavi, M.M., Mahmoudi, M., Majeed, A., Maleki, A., Maleki, S., Malekzadeh, R., Malta, D.C., Mamun, A.A., Manda, A.L., Manguerra, H., Mansour-Ghanaei, F., Mansouri, B., Mansournia, M.A., Mantilla Herrera, A.M., Maravilla, J.C., Marks, A., Martin, R.V., Martini, S., Martins-Melo, F.R., Masaka, A., Masoumi, S.Z., Mathur, M.R., Matsushita, K., Maulik, P.K., McAlinden, C., McGrath, J.J., McKee, M., Mehndiratta, M.M., Mehri, F., Mehta, K.M., Memish, Z.A., Mendoza, W., Menezes, R.G., Mengesha, E.W., Mereke, A., Mereta, S.T., Meretoja, A., Meretoja, T.J., Mestrovic, T., Miazgowski, B., Miazgowski, T., Michalek, I.M., Miller, T.R., Mills, E.J., Mini, G.K., Miri, M., Mirica, A., Mirrakhimov, E.M., Mirzaei, H., Mirzaei, M., Mirzaei, R., Mirzaei-Alavijeh, M., Misganaw, A.T., Mithra, P., Moazen, B., Mohammad, D.K., Mohammad, Y., Mohammad Gholi Mezerji, N., Mohammadian-Hafshejani, A., Mohammadifard, N., Mohammadpourhodki, R., Mohammed, A.S., Mohammed, H., Mohammed, J.A., Mohammed, S., Mokdad, A.H., Molokhia, M., Monasta, L., Mooney, M.D., Moradi, G., Moradi, M., Moradi-Lakeh, M., Moradzadeh, R., Moraga, P., Morawska, L., Morgado-da-Costa, J., Morrison, S.D., Mosapour, A., Mosser, J.F., Mouodi, S., Mousavi, S.M., Mousavi Khaneghah, A., Mueller, U.O., Mukhopadhyay, S., Mullany, E.C., Musa, K.I., Muthupandian, S., Nabhan, A.F., Naderi, M., Nagarajan, A.J., Nagel, G., Naghavi, M., Naghshtabrizi, B., Naimzada, M.D., Najafi, F., Nangia, V., Nansseu, J.R., Naserbakht, M., Nayak, V.C., Negoi, I., Ngunjiri, J.W., Nguyen, C.T., Nguyen, H.L.T., Nguyen, M., Nigatu, Y.T., Nikbakhsh, R., Nixon, M.R., Nnaji, C.A., Nomura, S., Norrving, B., Noubiap, J.J., Nowak, C., Nunez-Samudio, V., Oţoiu, A., Oancea, B., Odell, C.M., Ogbo, F.A., Oh, I.H., Okunga, E.W., Oladnabi, M., Olagunju, A.T., Olusanya, B.O., Olusanya, J.O., Omer, M.O., Ong, K.L., Onwujekwe, O.E., Orpana, H.M., Ortiz, A., Osarenotor, O., Osei, F.B., Ostroff, S.M., Otstavnov, N., Otstavnov, S.S., Øverland, S., Owolabi, M.O., P A, M., Padubidri, J.R., Palladino, R., Panda-Jonas, S., Pandey, A., Parry, C.D.H., Pasovic, M., Pasupula, D.K., Patel, S.K., Pathak, M., Patten, S.B., Patton, G.C., Pazoki Toroudi, H., Peden, A.E., Pennini, A., Pepito, V.C.F., Peprah, E.K., Pereira, D.M., Pesudovs, K., Pham, H.Q., Phillips, M.R., Piccinelli, C., Pilz, T.M., Piradov, M.A., Pirsaheb, M., Plass, D., Polinder, S., Polkinghorne, K.R., Pond, C.D., Postma, M.J., Pourjafar, H., Pourmalek, F., Poznańska, A., Prada, S.I., Prakash, V., Pribadi, D.R.A., Pupillo, E., Quazi Syed, Z., Rabiee, M., Rabiee, N., Radfar, A., Rafiee, A., Raggi, A., Rahman, M.A., Rajabpour-Sanati, A., Rajati, F., Rakovac, I., Ram, P., Ramezanzadeh, K., Ranabhat, C.L., Rao, P.C., Rao, S.J., Rashedi, V., Rathi, P., Rawaf, D.L., Rawaf, S., Rawal, L., Rawassizadeh, R., Rawat, R., Razo, C., Redford, S.B., Reiner, R.C. Jr, Reitsma, M.B., Remuzzi, G., Renjith, V., Renzaho, A.M.N., Resnikoff, S., Rezaei, N., Rezaei, N., Rezapour, A., Rhinehart, P.A.,
Riahi, S.M., Ribeiro, D.C., Ribeiro, D., Rickard, J., Rivera, J.A., Roberts, N.L.S., Rodríguez-Ramírez, S., Roever, L., Ronfani, L., Room, R., Roshandel, G., Roth, G.A., Rothenbacher, D., Rubagotti, E., Rwegerera, G.M., Sabour, S., Sachdev, P.S., Saddik, B., Sadeghi, E., Sadeghi, M., Saeedi, R., Saeedi Moghaddam, S., Safari, Y., Safi, S., Safiri, S., Sagar, R., Sahebkar, A., Sajadi, S.M., Salam, N., Salamati, P., Salem, H., Salem, M.R.R., Salimzadeh, H., Salman, O.M., Salomon, J.A., Samad, Z., Samadi Kafil, H., Sambala, E.Z., Samy, A.M., Sanabria, J., Sánchez-Pimienta, T.G., Santomauro, D.F., Santos, I.S., Santos, J.V., Santric-Milicevic, M.M., Saraswathy, S.Y.I., Sarmiento-Suárez, R., Sarrafzadegan, N., Sartorius, B., Sarveazad, A., Sathian, B., Sathish, T., Sattin, D., Saxena, S., Schaeffer, L.E., Schiavolin, S., Schlaich, M.P., Schmidt, M.I., Schutte, A.E., Schwebel, D.C., Schwendicke, F., Senbeta, A.M., Senthilkumaran, S., Sepanlou, S.G., Serdar, B., Serre, M.L., Shadid, J., Shafaat, O., Shahabi, S., Shaheen, A.A., Shaikh, M.A., Shalash, A.S., Shams-Beyranvand, M., Shamsizadeh, M., Sharafi, K., Sheikh, A., Sheikhtaheri, A., Shibuya, K., Shield, K.D., Shigematsu, M., Shin, J.I., Shin, M.J., Shiri, R., Shirkoohi, R., Shuval, K., Siabani, S., Sierpinski, R., Sigfusdottir, I.D., Sigurvinsdottir, R., Silva, J.P., Simpson, K.E., Singh, J.A., Singh, P., Skiadaresi, E., Skou, S.T., Skryabin, V.Y., Smith, E.U.R., Soheili, A., Soltani, S., Soofi, M., Sorensen, R.J.D., Soriano, J.B., Sorrie, M.B., Soshnikov, S., Soyiri, I.N., Spencer, C.N., Spotin, A., Sreeramareddy, C.T., Srinivasan, V., Stanaway, J.D., Stein, C., Stein, D.J., Steiner, C., Stockfelt, L., Stokes, M.A., Straif, K., Stubbs, J.L., Sufiyan, M.B., Suleria, H.A.R., Suliankatchi Abdulkader, R., Sulo, G., Sultan, I., Szumowski, Ł., Tabarés-Seisdedos, R., Tabb, K.M., Tabuchi, T., Taherkhani, A., Tajdini, M., Takahashi, K., Takala, J.S., Tamiru, A.T., Taveira, N., Tehrani-Banihashemi, A., Temsah, M.H., Tesema, G.A., Tessema, Z.T., Thurston, G.D., Titova, M.V., Tohidinik, H.R., Tonelli, M., Topor-Madry, R., Topouzis, F., Torre, A.E., Touvier, M., Tovani-Palone, M.R.R., Tran, B.X., Travillian, R., Tsatsakis, A., Tudor Car, L., Tyrovolas, S., Uddin, R., Umeokonkwo, C.D., Unnikrishnan, B., Upadhyay, E., Vacante, M., Valdez, P.R., van Donkelaar, A., Vasankari, T.J., Vasseghian, Y., Veisani, Y., Venketasubramanian, N., Violante, F.S., Vlassov, V., Vollset, S.E., Vos, T., Vukovic, R., Waheed, Y., Wallin, M.T., Wang, Y., Wang, Y.P., Watson, A., Wei, J., Wei, M.Y.W., Weintraub, R.G., Weiss, J., Werdecker, A., West, J.J., Westerman, R., Whisnant, J.L., Whiteford, H.A., Wiens, K.E., Wolfe, C.D.A., Wozniak, S.S., Wu, A.M., Wu, J., Wulf Hanson, S., Xu, G., Xu, R., Yadgir, S., Yahyazadeh Jabbari, S.H., Yamagishi, K., Yaminfirooz, M., Yano, Y., Yaya, S., Yazdi-Feyzabadi, V., Yeheyis, T.Y., Yilgwan, C.S., Yilma, M.T., Yip, P., Yonemoto, N., Younis, M.Z., Younker, T.P., Yousefi, B., Yousefi, Z., Yousefinezhadi, T., Yousuf, A.Y., Yu, C., Yusefzadeh, H., Zahirian Moghadam, T., Zamani, M., Zamanian, M., Zandian, H., Zastrozhin, M.S., Zhang, Y., Zhang, Z.J., Zhao, J.T., Zhao, X.J.G., Zhao, Y., Zhou, M., Ziapour, A., Zimsen, S.R.M., Brauer, M., Afshin, A., Lim, S.S., and the GBD 2019 Risk Factors Collaborators: Global burden of 87 risk factors in 204 countries and territories, 1990−2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet 396 (10258), 1223–1249 (2020) 3. Nichols, E., Steinmetz, J.D., Vollset, S.E., Fukutaki, K., Chalek, J., Abd-Allah, F., Abdoli, A., Abualhasan, A., Abu-Gharbieh, E., Akram, T.T., Al Hamad, H., Alahdab, F., Alanezi, F.M., Alipour, V., Almustanyir, S., Amu, H., Ansari, I., Arabloo, J., Ashraf, T., Astell-Burt, T., Ayano, G., Ayuso-Mateos, J.L., Baig, A.A., Barnett, A., Barrow, A., Baune, B.T., Béjot, Y., Bezabhe, W.M.M., Bezabih, Y.M., Bhagavathula, A.S., Bhaskar, S., Bhattacharyya, K., Bijani, A., Biswas, A., Bolla, S.R., Boloor, A., Brayne, C., Brenner, H., Burkart, K., Burns, R.A., Cámera, L.A., Cao, C., Carvalho, F., Castro-de-Araujo, L.F.S., Catalá-López, F., Cerin, E., Chavan, P.P., Cherbuin, N., Chu, D.T., Costa, V.M., Couto, R.A.S., Dadras, O., Dai, X., Dandona, L., Dandona, R., De la Cruz-Góngora, V., Dhamnetiya, D., Dias da Silva, D., Diaz, D., Douiri, A., Edvardsson, D., Ekholuenetale, M., El Sayed, I., El-Jaafary, S.I., Eskandari, K., Eskandarieh, S., Esmaeilnejad, S., Fares, J., Faro, A., Farooque, U., Feigin, V.L., Feng, X., Fereshtehnejad, S.M., Fernandes, E., Ferrara, P., Filip, I., Fillit, H., Fischer, F., Gaidhane, S., Galluzzo, L., Ghashghaee, A., Ghith, N., Gialluisi, A., Gilani, S.A., Glavan, I.R., Gnedovskaya, E.V., Golechha, M., Gupta, R., Gupta, V.B., Gupta, V.K., Haider, M.R., Hall, B.J., Hamidi, S., Hanif, A., Hankey, G.J., Haque, S., Hartono, R.K., Hasaballah, A.I., Hasan, M.T., Hassan, A., Hay, S.I., Hayat, K., Hegazy, M.I., Heidari, G., Heidari-Soureshjani, R., Herteliu, C., Househ, M., Hussain, R., Hwang, B.F., Iacoviello, L., Iavicoli, I., Ilesanmi, O.S., Ilic, I.M., Ilic, M.D., Irvani, S.S.N., Iso, H., Iwagami, M., Jabbarinejad, R., Jacob, L., Jain, V., Jayapal, S.K., Jayawardena, R., Jha, R.P., Jonas, J.B., Joseph, N., Kalani, R., Kandel, A., Kandel, H., Karch, A., Kasa, A.S., Kassie, G.M., Keshavarz, P., Khan, M.A.B., Khatib, M.N., Khoja, T.A.M., Khubchandani, J., Kim, M.S., Kim, Y.J., Kisa, A., Kisa, S., Kivimäki, M., Koroshetz, W.J., Koyanagi, A., Kumar, G.A., Kumar, M., Lak, H.M., Leonardi, M., Li, B., Lim, S.S., Liu, X., Liu, Y., Logroscino, G., Lorkowski, S., Lucchetti, G., Lutzky Saute, R., Magnani, F.G., Malik, A.A., Massano, J., Mehndiratta, M.M., Menezes, R.G., Meretoja, A., Mohajer, B., Mohamed Ibrahim, N., Mohammad, Y., Mohammed, A., Mokdad, A.H., Mondello, S., Moni, M.A.A., Moniruzzaman, M., Mossie, T.B., Nagel, G., Naveed, M., Nayak, V.C., Neupane Kandel, S., Nguyen, T.H., Oancea, B., Otstavnov, N., Otstavnov, S.S., Owolabi, M.O., Panda-Jonas, S., Pashazadeh Kan, F., Pasovic, M., Patel, U.K., Pathak, M., Peres, M.F.P., Perianayagam, A., Peterson, C.B., Phillips, M.R., Pinheiro, M., Piradov, M.A., Pond, C.D., Potashman, M.H., Pottoo, F.H., Prada, S.I., Radfar, A., Raggi, A., Rahim, F., Rahman, M., Ram, P., Ranasinghe, P., Rawaf, D.L., Rawaf, S., Rezaei, N., Rezapour, A., Robinson, S.R., Romoli, M., Roshandel, G., Sahathevan, R., Sahebkar, A., Sahraian, M.A., Sathian, B., Sattin, D., Sawhney, M., Saylan, M., Schiavolin, S., Seylani, A., Sha, F., Shaikh, M.A., Shaji, K.S., Shannawaz, M., Shetty, J.K., Shigematsu, M., Shin, J.I., Shiri, R., Silva, D.A.S., Silva, J.P., Silva, R., Singh, J.A., Skryabin, V.Y., Skryabina, A.A., Smith, A.E., Soshnikov, S., Spurlock, E.E., Stein, D.J., Sun, J., Tabarés-Seisdedos, R., Thakur, B., Timalsina, B., Tovani-Palone, M.R., Tran, B.X., Tsegaye, G.W., Valadan Tahbaz, S., Valdez, P.R., Venketasubramanian, N., Vlassov, V., Vu, G.T., Vu, L.G., Wang, Y.P., Wimo, A., Winkler, A.S., Yadav, L., Yahyazadeh Jabbari, S.H., Yamagishi, K., Yang, L., Yano, Y., Yonemoto, N., Yu, C., Yunusa, I., Zadey, S., Zastrozhin, M.S., Zastrozhina, A., Zhang, Z.J., Murray, C.J.L., Vos, T., and the GBD 2019 Dementia Forecasting Collaborators: Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019. Lancet Public Health 7(2), e105–e125 (2022) 4. Matthews, K.A., Xu, W., Gaglioti, A.H., Holt, J.B., Croft, J.B., Mack, D., McGuire, L.C.: Racial and ethnic estimates of Alzheimer’s disease and related dementias in the United States (2015–2060) in adults aged ≥65 years. Alzheimers Dement. 15(1), 17–24 (2019) 5. Howard, R., Liu, K.Y.: Questions EMERGE as Biogen claims aducanumab turnaround. Nat. Rev. Neurol. 16(2), 63–64 (2020)
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