Achieving high titer and yield in the bioconversion of l-threonine to 2-hydroxybutyric acid with Escherichia coli BL21
Author:
Funder
National Research Foundation of Korea
Publisher
Springer Science and Business Media LLC
Subject
Microbiology,Applied Microbiology and Biotechnology,Biochemistry, Genetics and Molecular Biology (miscellaneous),Food Science
Link
https://link.springer.com/content/pdf/10.1007/s43393-023-00224-w.pdf
Reference22 articles.
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2. Matsumoto K, Terai S, Ishiyama A, Sun J, Kabe T, Song Y, et al. One-pot microbial production, mechanical properties, and enzymatic degradation of isotactic P[( R )-2-hydroxybutyrate] and its copolymer with ( R )-lactate. Biomacromol. 2013;14:1913–8. https://doi.org/10.1021/bm400278j.
3. Park SJ, Lee TW, Lim S-C, Kim TW, Lee H, Kim MK, et al. Biosynthesis of polyhydroxyalkanoates containing 2-hydroxybutyrate from unrelated carbon source by metabolically engineered Escherichia coli. Appl Microbiol Biotechnol. 2012;93:273–83. https://doi.org/10.1007/s00253-011-3530-x.
4. Sudo M, Hori C, Ooi T, Mizuno S, Tsuge T, Matsumoto K. Synergy of valine and threonine supplementation on poly(2-hydroxybutyrate-block-3-hydroxybutyrate) synthesis in engineered Escherichia coli expressing chimeric polyhydroxyalkanoate synthase. J Biosci Bioeng. 2020;129:302–6. https://doi.org/10.1016/j.jbiosc.2019.09.018.
5. Ferrannini E, Natali A, Camastra S, Nannipieri M, Mari A, Adam K-P, et al. Early metabolic markers of the development of dysglycemia and type 2 diabetes and their physiological significance. Diabetes. 2013;62:1730–7. https://doi.org/10.2337/db12-0707.
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