Restored UBE2C expression in islets promotes β-cell regeneration in mice by ubiquitinating PER1
Author:
Funder
National Natural Science Foundation of China
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Cellular and Molecular Neuroscience,Pharmacology,Molecular Biology,Molecular Medicine
Link
https://link.springer.com/content/pdf/10.1007/s00018-023-04868-8.pdf
Reference55 articles.
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2. Mathieu C, Martens PJ, Vangoitsenhoven R (2021) One hundred years of insulin therapy. Nat Rev Endocrinol 17(12):715–725. https://doi.org/10.1038/s41574-021-00542-w
3. Eizirik DL, Pasquali L, Cnop M (2020) Pancreatic Î2-cells in type 1 and type 2 diabetes mellitus: different pathways to failure. Nat Rev Endocrinol 16(7):349–362. https://doi.org/10.1038/s41574-020-0355-7
4. Hudish LI, Reusch JE, Sussel L (2019) Î2 Cell dysfunction during progression of metabolic syndrome to type 2 diabetes. J Clin Investig 129(10):4001–4008. https://doi.org/10.1172/jci129188
5. Halban PA, Polonsky KS, Bowden DW et al (2014) Î2-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment. Diabetes Care 37(6):1751–1758. https://doi.org/10.2337/dc14-0396
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