What turns CREB on? And off? And why does it matter?-Reference-Cited by-同舟云学术

What turns CREB on? And off? And why does it matter?

Published:2020-04-28 Issue:20 Volume:77 Page:4049-4067
ISSN:1420-682X
Container-title:Cellular and Molecular Life Sciences
language:en
Short-container-title:Cell. Mol. Life Sci.

Author:

Steven André,Friedrich Michael,Jank Paul,Heimer Nadine,Budczies Jan,Denkert Carsten,Seliger Barbara

Abstract

AbstractAltered expression and function of the transcription factor cyclic AMP response-binding protein (CREB) has been identified to play an important role in cancer and is associated with the overall survival and therapy response of tumor patients. This review focuses on the expression and activation of CREB under physiologic conditions and in tumors of distinct origin as well as the underlying mechanisms of CREB regulation by diverse stimuli and inhibitors. In addition, the clinical relevance of CREB is summarized, including its use as a prognostic and/or predictive marker as well as a therapeutic target.

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Cellular and Molecular Neuroscience,Pharmacology,Molecular Biology,Molecular Medicine

Link

https://link.springer.com/content/pdf/10.1007/s00018-020-03525-8.pdf

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