Early trypsin activation develops independently of autophagy in caerulein-induced pancreatitis in mice-Reference-Cited by-同舟云学术

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Early trypsin activation develops independently of autophagy in caerulein-induced pancreatitis in mice

Published:2019-07-30 Issue:9 Volume:77 Page:1811-1825
ISSN:1420-682X
Container-title:Cellular and Molecular Life Sciences
language:en
Short-container-title:Cell. Mol. Life Sci.

Author:

Malla Sudarshan R.,Krueger Burkhard,Wartmann Thomas,Sendler Matthias,Mahajan Ujjwal M.,Weiss F. Ulrich,Thiel Franziska G.,De Boni Carina,Gorelick Fred S.,Halangk Walter,Aghdassi Ali A.,Reinheckel Thomas,Gukovskaya Anna S.,Lerch Markus M.^ORCID,Mayerle Julia

Funder

Dr. Mildred Scheel Stiftung für Krebsforschung

Deutsche Forschungsgemeinschaft

Bundesministerium für Bildung und Forschung

european union

European Social Fund

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Cellular and Molecular Neuroscience,Pharmacology,Molecular Biology,Molecular Medicine

Link

http://link.springer.com/content/pdf/10.1007/s00018-019-03254-7.pdf

Reference60 articles.

1. Whitcomb DC, Gorry MC, Preston RA et al (1996) Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet 14:141–145. https://doi.org/10.1038/ng1096-141

2. Witt H, Luck W, Hennies HC et al (2000) Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis. Nat Genet 25:213–216. https://doi.org/10.1038/76088

3. Whitcomb DC, LaRusch J, Krasinskas AM et al (2012) Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. Nat Genet 44:1349–1354. https://doi.org/10.1038/ng.2466

4. Gaiser S, Daniluk J, Liu Y et al (2011) Intracellular activation of trypsinogen in transgenic mice induces acute but not chronic pancreatitis. Gut 60:1379–1388. https://doi.org/10.1136/gut.2010.226175

5. Dawra R, Sah RP, Dudeja V et al (2011) Intra-acinar trypsinogen activation mediates early stages of pancreatic injury but not inflammation in mice with acute pancreatitis. Gastroenterology 141:2210–2217.e2. https://doi.org/10.1053/j.gastro.2011.08.033

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