Molecular modeling of apoE in complexes with Alzheimer’s amyloid-β fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids-Reference-Cited by-同舟云学术

Molecular modeling of apoE in complexes with Alzheimer’s amyloid-β fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids

Published:2023-11-27 Issue:12 Volume:80 Page:
ISSN:1420-682X
Container-title:Cellular and Molecular Life Sciences
language:en
Short-container-title:Cell. Mol. Life Sci.

Author:

Lewkowicz Emily^ORCID,Nakamura Mari N.,Rynkiewicz Michael J.^ORCID,Gursky Olga^ORCID

Funder

National Institute of General Medical Sciences

National Institute of Diabetes and Digestive and Kidney Diseases

National Heart, Lung, and Blood Institute

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Cellular and Molecular Neuroscience,Pharmacology,Molecular Biology,Molecular Medicine

Link

https://link.springer.com/content/pdf/10.1007/s00018-023-05026-w.pdf

Reference91 articles.

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2. Bloom GS (2014) Amyloid-β and Tau: the trigger and bullet in Alzheimer disease pathogenesis. JAMA Neurol 71:505. https://doi.org/10.1001/jamaneurol.2013.5847

3. Chen Y, Strickland MR, Soranno A, Holtzman DM (2021) Apolipoprotein E: structural insights and links to Alzheimer disease pathogenesis. Neuron 109:205–221. https://doi.org/10.1016/j.neuron.2020.10.008

4. Martens YA, Zhao N, Liu C-C, Kanekiyo T, Yang AJ, Goate AM, Holtzman DM, Bu G (2022) ApoE cascade hypothesis in the pathogenesis of Alzheimer’s disease and related dementias. Neuron 110:1304–1317. https://doi.org/10.1016/j.neuron.2022.03.004

5. Perneczky R, Jessen F, Grimmer T, Levin J, Flöel A, Peters O, Froelich L (2023) Anti-amyloid antibody therapies in Alzheimer’s disease. Brain 146:842–849. https://doi.org/10.1093/brain/awad005

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