Author:
Bonosi Lapo,Musso Sofia,Cusimano Luigi Maria,Porzio Massimiliano,Giovannini Evier Andrea,Benigno Umberto Emanuele,Giammalva Giuseppe Roberto,Gerardi Rosa Maria,Brunasso Lara,Costanzo Roberta,Paolini Federica,Sciortino Andrea,Campisi Benedetta Maria,Giardina Kevin,Scalia Gianluca,Iacopino Domenico Gerardo,Maugeri Rosario
Abstract
AbstractCervical spondylotic myelopathy (CSM) is a degenerative disease representing the most common spinal cord disorder in the adult population. It is characterized by chronic compression leading to neurological dysfunction due to static and dynamic injury of the spinal cord in cervical spine. These insidious damage mechanisms can result in the reorganization of cortical and subcortical areas. The cerebral cortex can reorganize due to spinal cord injury and may play a role in preserving neurological function. To date, the gold standard treatment of cervical myelopathy is surgery, comprising anterior, posterior, and combined approaches. However, the complex physiologic recovery processes involving cortical and subcortical neural reorganization following surgery are still inadequately understood. It has been demonstrated that diffusion MRI and functional imaging and techniques, such as transcranial magnetic stimulation (TMS) or functional magnetic resonance imaging (fMRI), can provide new insights into the diagnosis and prognosis of CSM. This review aims to shed light on the state-of-the-art regarding the pattern of cortical and subcortical areas reorganization and recovery before and after surgery in CSM patients, underlighting the critical role of neuroplasticity.
Funder
Università degli Studi di Palermo
Publisher
Springer Science and Business Media LLC
Subject
Neurology (clinical),General Medicine,Surgery
Cited by
3 articles.
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