Prediction of O(6)-methylguanine-DNA methyltransferase promoter methylation status in IDH-wildtype glioblastoma using MRI histogram analysis

Author:

Liu Xianwang,Han Tao,Wang Yuzhu,Liu Hong,Zhou Junlin

Funder

National Natural Science Foundation of China

2021 SKY Imaging Research Fund of China International Medical Exchange Foundation

Science and Technology Program of Gansu Province

Publisher

Springer Science and Business Media LLC

Reference22 articles.

1. Chen X, Zhang M, Gan H, Wang H, Lee JH, Fang D, Kitange GJ, He L, Hu Z, Parney IF, Meyer FB, Giannini C, Sarkaria JN, Zhang Z (2018) A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma. Nat Commun 9(1):2949. https://doi.org/10.1038/s41467-018-05373-4

2. Choi YS, Ahn SS, Kim DW, Chang JH, Kang SG, Kim EH, Kim SH, Rim TH, Lee SK (2016) Incremental prognostic value of ADC Histogram Analysis over MGMT promoter methylation status in patients with Glioblastoma. Radiology 281(1):175–184. https://doi.org/10.1148/radiol.2016151913

3. Drabycz S, Roldan G, de Robles P, Adler D, McIntyre JB, Magliocco AM, Cairncross JG, Mitchell JR (2010) An analysis of image texture, tumor location, and MGMT promoter methylation in glioblastoma using magnetic resonance imaging. NeuroImage 49(2):1398–1405. https://doi.org/10.1016/j.neuroimage.2009.09.049

4. Ellingson BM, Cloughesy TF, Pope WB, Zaw TM, Phillips H, Lalezari S, Nghiemphu PL, Ibrahim H, Naeini KM, Harris RJ, Lai A (2012) Anatomic localization of O6-methylguanine DNA methyltransferase (MGMT) promoter methylated and unmethylated tumors: a radiographic study in 358 de novo human glioblastomas. NeuroImage 59(2):908–916. https://doi.org/10.1016/j.neuroimage.2011.09.076

5. Gatto L, Franceschi E, Tosoni A, Di Nunno V, Tonon C, Lodi R, Agati R, Bartolini S, Brandes AA (2022) Beyond Imaging and Genetic Signature in Glioblastoma: radiogenomic holistic Approach in Neuro-Oncology. Biomedicines 10(12). https://doi.org/10.3390/biomedicines10123205

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