Cardiac Role of Cyclic-GMP Hydrolyzing Phosphodiesterase Type 5: From Experimental Models to Clinical Trials
Author:
Publisher
Springer Science and Business Media LLC
Subject
Physiology (medical),Cardiology and Cardiovascular Medicine,Emergency Medicine
Link
http://link.springer.com/content/pdf/10.1007/s11897-012-0101-0.pdf
Reference65 articles.
1. • Tsai EJ, Kass DA. Cyclic gmp signaling in cardiovascular pathophysiology and therapeutics. Pharmacol. Ther. 2009;122:216–38. This is a useful and fairly recent review focusing on cardiovascular role of the cGMP-PKG signaling pathway.
2. •• Francis SH, Busch JL, Corbin JD, Sibley D. Cgmp-dependent protein kinases and cgmp phosphodiesterases in nitric oxide and cgmp action. Pharmacol Rev. 2010;62:525-63. This is an excellent review focusing on the molecular biology and biochemistry of the cGMP phosphodiesterases, and their signaling via PKG.
3. Bender AT, Beavo JA. Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use. Pharmacol Rev. 2006;58:488–520.
4. • Zhang M, Kass DA. Phosphodiesterases and cardiac cgmp: Evolving roles and controversies. Trends Pharmacol Sci. 2011;32:360-365. This article discusses in particular the controversies surrounding which PDEs are most important to cardiac cGMP modulation in the heart, and the potential for this pathway to provide a novel therapeutic avenue.
5. Castro LR, Verde I, Cooper DM, Fischmeister R. Cyclic guanosine monophosphate compartmentation in rat cardiac myocytes. Circulation. 2006;113:2221–8.
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