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The impact of race on response to RAAS inhibition

  • Published:2005-06 Issue:2 Volume:2 Page:72-77
  • ISSN:1546-9530
  • Container-title:Current Heart Failure Reports
  • language:en
  • Short-container-title:Curr Heart Fail Rep

Author:

Wallace Thomas W.,Drazner Mark H.

Publisher

Springer Science and Business Media LLC

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Emergency Medicine

Reference23 articles.

1. Kaplan JB, Bennett T: Use of race and ethnicity in biomedical publication. JAMA 2003, 289:2709–2716.

2. Cooper RS, Kaufman JS, Ward R: Race and genomics. N Engl J Med 2003, 348:1166–1170.

3. Burchard EG, Ziv E, Coyle N, et al.: The importance of race and ethnic background in biomedical research and clinical practice. N Engl J Med 2003, 348:1170–1175.

4. Carson P, Ziesche S, Johnson G, Cohn JN: Racial differences in response to therapy for heart failure: analysis of the vasodilator-heart failure trials. Vasodilator-Heart Failure Trial Study Group. J Card Fail 1999, 5:178–187. This retrospective analysis of V-HeFT contrasts the relative efficacy of isosorbide dinitrate/hydralazine and enalapril in black patients versus white patients.

5. Dries DL, Strong MH, Cooper RS, Drazner MH: Efficacy of angiotensin-converting enzyme inhibition in reducing progression from asymptomatic left ventricular dysfunction to symptomatic heart failure in black and white patients. J Am Coll Cardiol 2002, 40:311–317. This retrospective analysis demonstrated that enalapril was equally efficacious in black patients and white patients in delaying the progression from ALVD to symptomatic heart failure. This analysis was conducted in follow-up to the study by Exner et al. [6] to see whether there was an ethnic disparity in the efficacy of enalapril for other outcomes. This study also confirmed the increased risk of adverse outcomes in black patients versus white patients first identified by Dries et al. [10] and here defined by the progression from ALVD to symptomatic heart failure.

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