Embryotoxicity induced by alkylating agents: 6. DNA adduct formation induced by methylnitrosourea in mouse embryos

Author:

Bochert Gerd,Platzek Thomas,Rahm Ute,Neubert Diether

Publisher

Springer Science and Business Media LLC

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

Reference43 articles.

1. Barbin A, Bartsch H (1989) Nucleophilic selectivity as a determinant of carcinogenic potency (TD50) in rodents: a comparison of mono- and bi-functional alkylating agents and vinyl chloride metabolites. Mutat Res 215: 95–106

2. Bartsch H, Terracini B, Malaveille C, Tomatis L, Wahrendorf J, Brun G, Dodet B (1983) Quantitative comparison of carcinogenicity, mutagenicity and electrophilicity of 10 direct-acting alkylating agents and of the initialO 6∶7-alkylguanine ratio in DNA with carcinogenic potency in rodents. Mutat Res 110: 181–219

3. Bochert G, Webb J (1977) The use of liquid ion-exchange chromatography for the determination of alkylated nucleic acid bases in maternal and fetal tissues. In: Neubert D, Merker H-J, Kwasigroch TE (eds) Methods in Prenatal Toxicology. G Thieme Publ, Stuttgart, pp 456–464

4. Bochert G, Platzek T, Rahm U, Webb J (1978a) Some new aspects in the study of DNA alkylation in embryonic and fetal tissues. In: Neubert D, Merker H-J, Nau H, Langman J (eds) Role of pharmacokinetics in prenatal and perinatal toxicology. G Thieme Publ, Stuttgart, pp 253–261

5. Bochert G, Rahm U, Schnieders B (1978b) Pharmacokinetics of embryotoxic direct-acting alkylating agents: Comparison of DNA alkylation of various maternal tissues and the embryo during organogenesis. In: Neubert D, Merker H-J, Nau H, Langman J (eds) Role of pharmacokinetics in prenatal and perinatal toxicology. G Thieme Publ, Stuttgart, pp 235–251

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