Pituitary adenomas secreting large amounts of prolactin may give false low values in immunoradiometric assays. The hook effect

Author:

Petakov Milan S.,Damjanović S. S.,Nikolić-Durović M. M.,Dragojlović Z. L.,Obradović S.,Gligorović M. S.,Simić M. Ž.,Popović V. P.

Publisher

Springer Science and Business Media LLC

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism

Reference16 articles.

1. Brensing A.K., Dahlmann N., Entzian W., Bidlingmaier F., Klingmuler D. Underestimation of LH and FSH hormone concentrations in a patient with a gonadotropin secreting tumor: the high dose “hook effect” as a methodological and clinical problem. Horm. Metab. Res. 21: 697, 1989.

2. Wolf B.A., Garrett N.C., Nahm M.H. The hook effect: high concentrations of prostate-specific antigen giving artifactually low values on one-step immunoassay. N. Engl. J. Med. 320: 1755, 1989.

3. Zweig M.H., Csako G. High-dose hook effect in a two site IRMA for measuring thyrotropin. Ann. Clin. Biochem. 27: 494, 1990.

4. Saryan J.A., Garret P.K., Kurtz S.R. Failure to detect extremely high levels of serum IgE with an immunoradiometric assay. Ann. Allergy 63: 322, 1989.

5. Comtois R., Robert F., Hardy J. Immunoradiometric assay may miss high prolactin levels. Ann. Intern. Med. 119: 173, 1993.

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