To the editor: Following is our response to the comments by Tonnet al

Author:

Hand Christopher M.,Jordan Joseph P.,McCormack Thomas,Black Perry

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Clinical Neurology,Neurology,Oncology

Reference13 articles.

1. Hongo T, Fujii Y, Igarashi Y: Anin vitro chemosensitivity test for the screening of anti-cancer drugs in childhood leukemia. Cancer 65: 1263?1271, 1990

2. Von Hoff DD, Clark GM, Stogdill BJ, Sarodsy MF, O'Brien MT, Casper JT, Mattox DE, Page CP, Cruz AB, Sandbach JF: Prospective clinical trial of a human tumor-cloning system. Cancer Res 43: 1926?1931, 1983

3. Metcalfe SA: A review of methods for estimating clinically achievable antitumour drug levels and their association with studiesin vitro. In: Dendy PP, Hill BT (eds) Human Tumour Drug Sensitivity TestingIn Vitro. Academic Press: London, 1983, p 213?224

4. Nikkhah G, Tonn JC, Hoffman O, Kraemer HP, Darling JL, Schonmayr R: The MTT assay for chemosensitivity testing of human tumors of the central nervous system: Part I: Evaluation of test-specific variables. J Neuro-Oncol 13: 1?11, 1992

5. Nikkhah G, Tonn JC, Hoffman O, Kraemer HP, Darling JL, Schachenmayr W, Schonmayr R: The MTT assay for chemosensitivity testing of human tumors of the central nervous system: Part II: Evaluation of patient- and drug-specific variables. J Neuro-Oncol 13: 13?24, 1992

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