Author:
Ottka Claudia,Puurunen Jenni,Müller Elisabeth,Weber Corinna,Klein Ruth,Lohi Hannes
Abstract
Abstract
Introduction
Metabolomics studies in canine endocrine abnormalities are sparse and basic information on these abnormalities must be generated.
Objectives
To characterize the metabolic changes associated with elevated fructosamine, reflecting poor glycemic control, and low thyroxine, a thyroid hormone controlling metabolism.
Methods
Leftovers of clinical serum samples; 25 controls, 79 high fructosamine, and 47 low thyroxine, were analyzed using 1H NMR and differences were evaluated using Firth logistic regression.
Results
Both high fructosamine and low thyroxine were associated with changes in concentrations of multiple metabolites, including glycoprotein acetyls and lipids.
Conclusion
These findings suggest promising makers for further research and clinical validation.
Funder
PetBiomics Ltd.
LABOKLIN GmbH & Co KG
University of Helsinki including Helsinki University Central Hospital
Publisher
Springer Science and Business Media LLC
Subject
Clinical Biochemistry,Biochemistry,Endocrinology, Diabetes and Metabolism