Metabolic consequences of LDHA inhibition by epigallocatechin gallate and oxamate in MIA PaCa-2 pancreatic cancer cells

Author:

Lu Qing-Yi,Zhang Lifeng,Yee Jennifer K.,Go Vay-Liang W.,Lee Wai-Nang

Publisher

Springer Science and Business Media LLC

Subject

Clinical Biochemistry,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference40 articles.

1. Bardeesy, N., & DePinho, R. A. (2002). Pancreatic cancer biology and genetics. Nature Reviews Cancer, 2(12), 897–909. doi: 10.1038/nrc949 .

2. Boren, J., Cascante, M., Marin, S., Comin-Anduix, B., Centelles, J. J., Lim, S., et al. (2001). Gleevec (STI571) influences metabolic enzyme activities and glucose carbon flow toward nucleic acid and fatty acid synthesis in myeloid tumor cells. Journal of Biological Chemistry, 276(41), 37747–37753. doi: 10.1074/jbc.M105796200 .

3. Boros, L. G., Bassilian, S., Lim, S., & Lee, W. N. (2001). Genistein inhibits nonoxidative ribose synthesis in MIA pancreatic adenocarcinoma cells: A new mechanism of controlling tumor growth. Pancreas, 22(1), 1–7.

4. Boros, L. G., Puigjaner, J., Cascante, M., Lee, W. N., Brandes, J. L., Bassilian, S., et al. (1997). Oxythiamine and dehydroepiandrosterone inhibit the nonoxidative synthesis of ribose and tumor cell proliferation. Cancer Research, 57(19), 4242–4248.

5. Boros, L. G., Torday, J. S., Lim, S., Bassilian, S., Cascante, M., & Lee, W. N. (2000). Transforming growth factor beta2 promotes glucose carbon incorporation into nucleic acid ribose through the nonoxidative pentose cycle in lung epithelial carcinoma cells. Cancer Research, 60(5), 1183–1185.

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