Untargeted metabolomics reveals a mild impact of remote ischemic conditioning on the plasma metabolome and α-hydroxybutyrate as a possible cardioprotective factor and biomarker of tissue ischemia

Author:

Laursen Mia Roest,Hansen Jakob,Elkjær Casper,Stavnager Ninna,Nielsen Camilla Bak,Pryds Kasper,Johnsen Jacob,Nielsen Jan Møller,Bøtker Hans Erik,Johannsen MogensORCID

Funder

Danish Council for Independant Research

Strategiske Forskningsråd

Foundation Leducq

Karen Elise Jensens Fond

Publisher

Springer Science and Business Media LLC

Subject

Clinical Biochemistry,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference57 articles.

1. Bøtker, H. E., Kharbanda, R., Schmidt, M. R., Bøttcher, M., Kaltoft, A. K., Terkelsen, C. J., et al. (2010). Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: A randomised trial. Lancet, 375(9716), 727–734. doi: 10.1016/S0140-6736(09)62001-8 .

2. Breivik, L., Helgeland, E., Aarnes, E. K., Mrdalj, J., & Jonassen, A. K. (2010). Remote postconditioning by humoral factors in effluent from ischemic preconditioned rat hearts is mediated via PI3K/Akt-dependent cell-survival signaling at reperfusion. Basic Research in Cardiology, 106(1), 135–145. doi: 10.1007/s00395-010-0133-0 .

3. Chaudary, N., Naydenova, Z., Shuralyova, I., & Coe, I. R. (2004). The adenosine transporter, mENT1, is a target for adenosine receptor signaling and protein kinase Cepsilon in hypoxic and pharmacological preconditioning in the mouse cardiomyocyte cell line, HL-1. The Journal of Pharmacology and Experimental Therapeutics, 310(3), 1190–1198. doi: 10.1124/jpet.104.067157 .

4. Claycomb, W. C., Lanson, N. A., Stallworth, B. S., Egeland, D. B., Delcarpio, J. B., Bahinski, A., & Izzo, N. J. (1998). HL-1 cells: A cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte. Proceedings of the National Academy of Sciences of the United States of America, 95(6), 2979–2984.

5. Dickson, E. W., Lorbar, M., Porcaro, W. A., Fenton, R. A., Reinhardt, C. P., Gysembergh, A., & Przyklenk, K. (1999). Rabbit heart can be “preconditioned” via transfer of coronary effluent. American Journal of Physiology: Heart and Circulatory Physiology, 277(6), H2451–H2457.

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