Clinico-Pathological Significance and Prognostic Impact of Various PML RARA Transcripts on Outcomes in Acute Promyelocytic Myeloid Leukemia (APML) Treated with Single Agent Arsenic Trioxide(ATO)- Insights from a Tertiary Cancer Center in South India

Author:

Sindhusha. K,C Saldanha SmithaORCID,Abraham Jacob Linu,Suresh Babu M.C.,Lokesh K. N.,Rudresha A. H.,Rajeev L. K.

Publisher

Springer Science and Business Media LLC

Reference18 articles.

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2. Melnick A, Licht JD (1999) Deconstructing a disease: RAR, its Fusion partners, and their roles in the pathogenesis of Acute promyelocytic leukemia. Blood J Am Soc Hematol 93(10):3167–3215

3. de Thé H, Chomienne C, Lanotte M et al (1990) The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus. Nature 347(6293):558–561

4. Grimwade D, Biondi A, Mozziconacci MJ, Hagemeijer A, Berger R, Neat M et al (2000) Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): results of the European Working Party. Groupe Francais De CytogenetiqueHematologique, Groupe De Francaisd’HematologieCellulaire, UK Cancer Cytogenetics Group and BIOMED 1 European Community-Concerted Action Molecular Cytogenetic diagnosis in Haematological Malignancies. Blood 96(4):1297–1308 PMid:10942371

5. Sanz MA, Lo CF, Martin G, Avvisati G, Rayon C, Barbui T et al (2000) Definition of relapse risk and role of non-anthracycline drugs for consolidation in patients with acute promyelocytic leukemia: a joint study of the PETHEMA and GIMEMA cooperative groups. Blood 96:1247–1253

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