Evaluation of continuous-infusion alpha-difluoromethylornithine therapy for colorectal carcinoma

Author:

Ajani Jaffer A.,Ota David M.,Grossie V. Bruce,Abbruzzese James L.,Faintuch Jack S.,Patt Yehuda Z.,Jackson Diane E.,Levin Bernard,Nishioka Kenji

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference27 articles.

1. Abeloff MD, Slavik M, Luk GD, Griffin CA, Hermann J, Blanc O, Sjoerdsma A, Baylin SB (1984) Phase I trial and pharmacokinetic studies of alpha-difluoromethylornithine. An inhibitor of polyamine synthesis. J Clin Oncol 2: 124–130

2. Ajani JA, Ota DM, Grossie VB, Levin B, Nishioka K (1989) Alterations in polyamine metabolism during continuous intravenous infusion of alpha-difluoromethylornithine: correlation of thrombocytopenia with alpha-difluoromethylornithine plasma levels. Cancer Res 49: 5761–5765

3. Ajani JA, Welch SR, Raber MN, Fields WS, Krakoff IH (1989) Comprehensive criteria for therapy-induced toxicity. Cancer Invest 8: 141–153

4. Bjerkvig R, Oredsson SM, Marton LJ, Linden M, Deen DF (1983) Cell cycle age response of 9L cells to 1,3-bis(2-chloroethyl)-1-nitrosourea and modification by alpha-difluoromethylornithine. Cancer Res 43: 1497–1500

5. Ducore JM, McNamara L (1986) Effect of alpha-difluoromethylornithine onl-phenylalanine mustard-induced cytotoxicity and DNA interstrand cross-linking in a human cell line in vitro. Cancer Res 46: 1068–1072

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