The Brave New World of Epigenetics: Embracing Complexity in the Study of Speech and Language Disorders

Author:

Kraft Shelly Jo,DeThorne Laura Segebart

Publisher

Springer Science and Business Media LLC

Subject

Psychiatry and Mental health,Developmental Neuroscience,Developmental and Educational Psychology

Reference52 articles.

1. Bishop DVM, Hayiou-Thomas ME. Heritability of specific language impairment depends on diagnostic criteria. Genes Brai Behavior. 2008;7:365–72.

2. Caylak, E. (2011). Biological/Biochemical features and molecular genetics of specific language impairment (SLI). In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net . doi: 10.1002/9780470015902.a0023688

3. Tallal P, Hirsch LS, Raelpe-Bonilla T. Familial aggregation in specific language impairment. J Speech Lang Hear Res. 2001;44:1172–82.

4. Rice ML. Toward epigenetic and gene regulation models of specific language impairment: looking for links among growth, genes, and impairments. J Neurodevelopmental Disorders. 2012;4(27):1–15. This article appeared within a special issue focused on epigenetics in the study of the etiology of language, speech, and reading impairments. It is one of the first publications to discuss epigenetics as applicable to SLI, particularly in regard to elements of grammatical development across the school-age years. Specifically, the author proposes a growth-signaling disruption hypothesis to characterize SLI.

5. Day JJ, Sweatt JD. Epigenetic models in cognition. Neuron. 2011;70:813–29. This article offers a specific description of how epigenetic processes within postmitotic neurons may be contributing to learning and memory, particularly through a ‘histone code.’ The authors also touch upon epigenetically based disorders related to speech-language development, such as Rett syndrome, and offer examples of novel therapeutic interventions.

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