Peto’s paradox revisited: black box vs mechanistic approaches to understanding the roles of mutations and promoting factors in cancer

Author:

Balmain AllanORCID

Funder

Cancer Research UK

National Cancer Center

Publisher

Springer Science and Business Media LLC

Subject

Epidemiology

Reference53 articles.

1. Peto R The need for ignorance in cancer research. In Encyclopedia of medical ignorance, 129–133 (1984).

2. Armitage P, Doll R. The age distribution of cancer and a multi-stage theory of carcinogenesis. Br J Cancer. 1954;8:1–12.

3. Peto R, Roe FJC, Lee PN, Levy I, Clack J. Cancer and ageing in mice and men. Br J Cancer. 1975;32:411.

4. Peto R. Epidemiology, multistage models, and short-term mutagenicity tests. In Hiatt HH, Watson JD, Winsten JA (eds), Origins of Human Cancer: New York, Cold Spring Harbor Laboratory, 1977:1403–1428.

5. Vincze O, et al. Cancer Risk Across Mammals. Nature. 2022;601:263.

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