The Direct Effects of Fingolimod in the Central Nervous System: Implications for Relapsing Multiple Sclerosis

Author:

Hunter Samuel F.,Bowen James D.,Reder Anthony T.

Funder

Novartis Pharmaceuticals Corporation (US)

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Psychiatry and Mental health,Neurology (clinical)

Reference125 articles.

1. Brinkmann V. FTY720 (fingolimod) in multiple sclerosis: therapeutic effects in the immune and the central nervous system. Br J Pharmacol. 2009;158(5):1173–82.

2. Chun J, Hartung HP. Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis. Clin Neuropharmacol. 2010;33(2):91–101.

3. Brinkmann V. Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology. Pharmacol Ther. 2007;115(1):84–105.

4. Food and Drug Administration. Gilenya US prescribing information. Revised August 2015. 2010 [cited 29 September 2015]. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/022527s019lbl.pdf .

5. European Medicines Agency. Gilenya EU summary of product characteristics, latest update of May 2015. 2011 [cited 16 June 2015]. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002202/WC500104528.pdf .

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