Soluble Vascular Cell Adhesion Molecule-1 (sVCAM-1) and Natalizumab Serum Concentration as Potential Biomarkers for Pharmacodynamics and Treatment Response of Patients with Multiple Sclerosis Receiving Natalizumab-Reference-Cited by-同舟云学术

Soluble Vascular Cell Adhesion Molecule-1 (sVCAM-1) and Natalizumab Serum Concentration as Potential Biomarkers for Pharmacodynamics and Treatment Response of Patients with Multiple Sclerosis Receiving Natalizumab

Published:2022-09-29 Issue:10 Volume:36 Page:1121-1131
ISSN:1172-7047
Container-title:CNS Drugs
language:en
Short-container-title:CNS Drugs

Author:

Auer Michael^ORCID,Bauer Angelika,Oftring Antonia,Rudzki Dagmar,Hegen Harald,Bsteh Gabriel,Di Pauli Franziska,Berek Klaus,Zinganell Anne,Berger Thomas,Reindl Markus,Deisenhammer Florian

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Psychiatry and Mental health,Neurology (clinical)

Link

https://link.springer.com/content/pdf/10.1007/s40263-022-00953-x.pdf

Reference37 articles.

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2. Polman CH, O’Connor PW, Havrdova E, Hutchinson M, Kappos L, Miller DH, AFFIRM Investigators, et al. A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N Engl J Med. 2006;354:899–910. https://doi.org/10.1056/NEJMoa044397.

3. Rudick RA, Stuart WH, Calabresi PA, Confavreux C, Galetta SL, Radue EW, SENTINEL Investigators, et al. Natalizumab plus interferon beta-1a for relapsing multiple sclerosis. N Engl J Med. 2006;354:911–23. https://doi.org/10.1056/NEJMoa044396.

4. Calabresi PA, Prat A, Biernacki K, Rollins J, Antel JP. T lymphocytes conditioned with Interferon beta induce membrane and soluble VCAM on human brain endothelial cells. J Neuroimmunol. 2001;115:161–7. https://doi.org/10.1016/s0165-5728(01)00253-3.

5. Garton KJ, Gough PJ, Philalay J, Wille PT, Blobel CP, Whitehead RH, et al. Stimulated shedding of vascular cell adhesion molecule 1 (VCAM-1) is mediated by tumor necrosis factor-alpha-converting enzyme (ADAM 17). J Biol Chem. 2003;278:37459–64. https://doi.org/10.1074/jbc.M305877200.

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