Diroximel Fumarate Demonstrates an Improved Gastrointestinal Tolerability Profile Compared with Dimethyl Fumarate in Patients with Relapsing–Remitting Multiple Sclerosis: Results from the Randomized, Double-Blind, Phase III EVOLVE-MS-2 Study

Author:

Naismith Robert T., ,Wundes Annette,Ziemssen Tjalf,Jasinska Elzbieta,Freedman Mark S.,Lembo Anthony J.,Selmaj Krzysztof,Bidollari Ilda,Chen Hailu,Hanna Jerome,Leigh-Pemberton Richard,Lopez-Bresnahan Maria,Lyons Jennifer,Miller Catherine,Rezendes David,Wolinsky Jerry S.

Funder

Alkermes Inc.

Biogen

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Psychiatry and Mental health,Neurology (clinical)

Reference21 articles.

1. Biogen. Vumerity® (diroximel fumarate) prescribing information and patient information. 2019. https://www.vumerity.com/content/dam/commercial/vumerity/pat/en_us/pdf/vumerity-prescribing-information.pdf. Accessed 19 Dec 2019.

2. Biogen. Tecfidera® (dimethyl fumarate) prescribing information and patient information. 2019. https://www.tecfidera.com/content/dam/commercial/multiple-sclerosis/tecfidera/pat/en_us/pdf/full-prescribing-info.pdf. Accessed 9 Apr 2019.

3. Wehr A, Hard M, Yu M, Leigh-Pemberton R, von Moltke L. Relative bioavailability of monomethyl fumarate after administration of ALKS 8700 and dimethyl fumarate in healthy subjects. Neurology. 2018;90(Suppl. 15):P1.403.

4. Gold R, Kappos L, Arnold DL, Bar-Or A, Giovannoni G, Selmaj K, DEFINE Study Investigators, et al. Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis. N Engl J Med. 2012;367(12):1098–107.

5. Fox RJ, Miller DH, Phillips JT, Hutchinson M, Havrdova E, Kita M, CONFIRM Study Investigators, et al. Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis. N Engl J Med. 2012;367(12):1087–97.

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