Safety, Tolerability and Efficacy of Eslicarbazepine Acetate as Adjunctive Therapy in Patients Aged ≥ 65 Years with Focal Seizures

Author:

Costa Raquel,Steinhoff Bernhard,Gama Helena,Ikedo Fábio,Rocha José-Francisco,Soares-da-Silva Patrício

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Geriatrics and Gerontology

Reference21 articles.

1. CHMP/EWP/566/98 rev 2, Committee for medicinal products for human use. Guideline on clinical investigation of medicinal products in the treatment of epileptic disorders. July 2 http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2010/01/WC500070043.pdf . Accessed 25 Sept 2018.

2. CPMP/ICH/379/95, International Conference of Harmonisation (ICH) E7. Studies in Support of Special Populations: Geriatrics. 1994. http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500002875.pdf . Accessed 25 Sept 2018.

3. Motika PV, Spencer DC. Treatment of epilepsy in the elderly. Curr Neurol Neurosci Rep. 2016;16(11):96.

4. Almeida L, Soares da Silva P. Eslicarbazepine acetate (BIA 2-093). Neurotherapeutics. 2007;4(1):88–96.

5. Bonifacio MJ, Sheridan RD, Parada A, Cunha RA, Patmore L, Soares da Silva P. Interaction of the novel anticonvulsant, BIA 2 093, with voltage-gated sodium channels: comparison with carbamazepine. Epilepsia. 2001;42(5):600–8.

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