Opioid Initiation and the Hazard of Falls or Fractures Among Older Adults with Varying Levels of Central Nervous System Depressant Burden

Author:

Guan QiORCID,Men Siyu,Juurlink David N.,Bronskill Susan E.ORCID,Wunsch HannahORCID,Gomes TaraORCID

Funder

CIHR

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Geriatrics and Gerontology

Reference28 articles.

1. Canadian Centre on Substance Use and Addiction. Sedatives (Canadian drug summary) [Internet]. 2019. https://www.ccsa.ca/sites/default/files/2019-06/CCSA-Canadian-Drug-Summary-Sedatives-2019-en.pdf.

2. Busse JW, Craigie S, Juurlink DN, Buckley DN, Wang L, Couban RJ, et al. Guideline for opioid therapy and chronic noncancer pain. Can Med Assoc J. 2017;189:E659–66.

3. Aspinall SL, Springer SP, Zhao X, Cunningham FE, Thorpe CT, Semla TP, et al. Central nervous system medication burden and risk of recurrent serious falls and hip fractures in veterans affairs nursing home residents: CNS medication burden and risk of falls. J Am Geriatr Soc. 2019;67:74–80.

4. Gerlach LB, Olfson M, Kales HC, Maust DT. Opioids and other central nervous system-active polypharmacy in older adults in the United States. J Am Geriatr Soc. 2017;65:2052–6.

5. US Food and Drug Administration. FDA Drug Safety Communication: FDA warns about serious risks and death when combining opioid pain or cough medications with benzodiazepines; requires its strongest warning [Internet]. https://www.fda.gov/drugs/drugsafety/ucm518473.htm. Accessed 10 Jan 2019.

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