Sterol O-Acyltransferase 2-Driven Cholesterol Esterification Opposes Liver X Receptor-Stimulated Fecal Neutral Sterol Loss

Author:

Warrier Manya12,Zhang Jun2,Bura Kanwardeep2,Kelley Kathryn2,Wilson Martha D.2,Rudel Lawrence L.2,Brown J. Mark12

Affiliation:

1. ; Department of Cellular and Molecular Medicine; Cleveland Clinic Lerner Research Institute; Cleveland OH 44195 USA

2. ; Department of Pathology; Wake Forest School of Medicine; Winston-Salem NC 27157 USA

Funder

National Heart, Lung, and Blood Institute

National Institutes of Health

Publisher

Wiley

Subject

Cell Biology,Organic Chemistry,Biochemistry

Reference52 articles.

1. Heart disease and stroke statistics-2011 update: a report from the American Heart Association;Roger;Circulation,2011

2. (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report;Third report of the National Cholesterol Education Program;Circulation,2002

3. ACAT2 is a target for treatment of coronary heart disease associated with hypercholesterolemia;Rudel;Arterioscler Thromb Vasc Biol,2005

4. ACAT inhibition and the progression of coronary atherosclerosis;Rudel;N Engl J Med,2006

5. Acyltransferase inhibitors: a patent review (2010-present);Oshiro;Expert Opin Ther Pat,2015

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