Advances in Intra-abdominal Sepsis: What Is New?

Author:

Dietch Zachary C.,Shah Puja M.,Sawyer Robert G.

Publisher

Springer Science and Business Media LLC

Subject

Infectious Diseases

Reference23 articles.

1. Shirah GR, O’Neill PJ. Intra-abdominal infections. Surg Clin N Am. 2014;94:1319–33. This important multicenter, double-blind, randomized controlled trial describes the results of administering a novel antibiotic, ceftolozane/tazobactom, to cIAI patients, when compared to the current gold standard.

2. Solomkin JS et al. Diagnosis and management of complicated intra-abdominal infections in adults and children. guidelines by the surgical infection society and the infectious diseases society of America. Clin Infect Dis Off Publ Infect Dis Soc Am. 2009;50. This is a multicenter, retrospective study evaluating different levels of procalcitonin and the role of procalcitonin in driving duration of antibiotic therapy. There is increasing evidence that procalcitonin correlates with disease severity.

3. Solomkin JS, Mazuski JE, Bradley JS, Rodvold KA, Goldstein EJ, Baron EJ, et al. Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection Society and the Infectious Diseases Society of America. Surg Infect. 2010;11:79–109.

4. Sartelli M et al. Complicated intra-abdominal infections worldwide: the definitive data of the CIAOW Study. World J Emerg Surg. 2014;9:37.

5. Solomkin J et al. Ceftolozane/tazobactum plus metronidazole for complicated intra-abdominal infections in an era of multidrug resistance: results from a randomized, double-blind, phase 3 trial (ASPECT-cIAI). Clin Infect Dis. 2015;60:1462–71. An important prospective, double-blind non-inferiority trial randomizing patients to ceftolozane/tazobactam plus metronidazole versus meropenem. The outcomes demonstrate that ceftolozame/tazobactam is non-inferior, even in patients with multi-drug resistant organisms.

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