Dexmedetomidine Alleviates CCI-Induced Neuropathic Pain via Inhibiting HMGB1-Mediated Astrocyte Activation and the TLR4/NF-κB Signaling Pathway in Rats

Author:

Zhao Erxian,Bai Liying,Li Shurong,Li Li,Dou Zhongci,Huang Yunli,Li Yan,Lv Yunqi

Publisher

Springer Science and Business Media LLC

Subject

Toxicology,General Neuroscience

Reference35 articles.

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2. Brambilla L, Martorana F, Guidotti G, Rossi D (2018) Dysregulation of astrocytic HMGB1 signaling in amyotrophic lateral sclerosis. Front Neurosci 12:622

3. Chen Y, Chen X, Yu J, Xu X, Wei X, Gu X, Liu C, Zhang D, Xu Z (2016) JAB1 is involved in neuropathic pain by regulating JNK and NF-κB activation after chronic constriction injury. Neurochem Res 41:1119–1129

4. Chen H, Hu Y, Xie K, Chen Y, Wang H, Bian Y, Wang Y, Dong A, Yu Y (2018) Effect of autophagy on allodynia, hyperalgesia and astrocyte activation in a rat model of neuropathic pain. Int J Mol Med 42:2009–2019

5. Clark AK, Old EA, Malcangio M (2013) Neuropathic pain and cytokines: current perspectives. J Pain Res 6:803–814

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