JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species-Reference-Cited by-同舟云学术

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JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species

Published:2022-08-23 Issue:6 Volume:40 Page:2135-2147
ISSN:1029-8428
Container-title:Neurotoxicity Research
language:en
Short-container-title:Neurotox Res

Author:

Santos Cleonice Creusa,Cardim-Pires Thyago R.,Shvachiy Liana,Fonseca-Fonseca Luis Arturo,Muñoz Patricia,Almeida Áurea Maria A. N.,Costa Ana Carla S.,Teles-Souza Jéssica,Ochoa-Rodríguez Estael,de Fátima Dias Costa Maria,Palhano Fernando L.,Segura-Aguilar Juan,Barbosa Deyse B.,do Bomfim Mayra R.,dos Santos Junior Manoelito C.,Leite Franco Henrique A.,da Rocha Pita Samuel Silva,Costa Silvia Lima,Núñez-Figueredo Yanier,Outeiro Tiago Fleming,Foguel Débora,Silva Victor Diogenes Amaral

Funder

Coordenação de Apoio de Pessoal de Nível Superior

Fundação para Ciência e Tecnologia

Conselho Nacional de Desenvolvimento Científico e Tecnológico

CENAPAD-SP (National Center for High Performance Computing in São Paulo), UNICAMP / FINEP – MCT

Deutsche Forschungsgemeinschaft

Publisher

Springer Science and Business Media LLC

Subject

Toxicology,General Neuroscience

Link

https://link.springer.com/content/pdf/10.1007/s12640-022-00559-7.pdf

Reference62 articles.

1. Abraham MJ, Murtola T, Schulz R, Páll S, Smith JC, Hess B, Lindahl E (2015) Gromacs: high performance molecular simulations through multi-level parallelism from laptops to supercomputers. SoftwareX 1–2:19–25. https://doi.org/10.1016/j.softx.2015.06.001

2. Alvarez-Castelao B, Castaño JG (2011) Synphilin-1 inhibits alpha-synuclein degradation by the proteasome. Cell Mol Life Sci 68(15):2643–2654

3. Arlehamn CS, Lindestam RD, Pham J, Kuan R, Frazier A, Dutra JR, Phillips E, Mallal S, Roederer M, Marder KS (2020) Α-synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease. Nat Commun 11(1):1–11

4. Bellomo G, Paciotti S, Gatticchi L, Parnetti L (2020) The vicious cycle between Α-synuclein aggregation and autophagic-lysosomal dysfunction. Mov Disord 35(1):34–44

5. Bender A, Desplats P, Spencer B, Rockenstein E, Adame A, Elstner M, Laub C, Mueller S, Koob AO, Mante M (2013) Tom40 mediates mitochondrial dysfunction induced by Α-synuclein accumulation in Parkinson’s disease.". PLoS ONE 8(4):e62277

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3. JM-20 administration to animals with lesion of the nigrostriatal dopamine pathway induced by 6-hydroxydopamine, partially reverses motor damage and oxidative stress;2024-08-01

4. JM-20 potently prevents the onset of caffeine-induced anxiogenic phenotypes in zebrafish (Danio rerio);Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology;2024-03

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