Radiofrequency ablation for locally advanced pancreatic cancer: SMAD4 analysis segregates a responsive subgroup of patients

Author:

Paiella SalvatoreORCID,Malleo Giuseppe,Cataldo Ivana,Gasparini Clizia,De Pastena Matteo,De Marchi Giulia,Marchegiani Giovanni,Rusev Borislav,Scarpa Aldo,Girelli Roberto,Giardino Alessandro,Frigerio Isabella,D’Onofrio Mirko,Secchettin Erica,Bassi Claudio,Salvia Roberto

Funder

Associazione Italiana per la Ricerca sul Cancro

FP7 Ideas: European Research Council

FIMP-Ministero della Salute

Publisher

Springer Science and Business Media LLC

Subject

Surgery

Reference31 articles.

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2. Blackford A, Serrano OK, Wolfgang CL, Parmigiani G, Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Eshleman JR, Goggins M, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Cameron JL, Olino K, Schulick R, Winter J, Herman JM, Laheru D, Klein AP, Vogelstein B, Kinzler KW, Velculescu VE, Hruban RH (2009) SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer. Clin Cancer Res 15(14):4674–4679. https://doi.org/10.1158/1078-0432.CCR-09-0227

3. Seufferlein T, Van Laethem JL, Van Cutsem E, Berlin JD, Buchler M, Cervantes A, Haustermans K, Hidalgo M, O’Reilly EM, Verslype C, Schmiegel W, Rougier P (2014) The management of locally advanced pancreatic cancer: European Society of Digestive Oncology (ESDO) expert discussion and recommendations from the 14th ESMO/ World Congress on Gastrointestinal Cancer, Barcelona. Ann Oncol 25(Supplement 2):ii1–ii4. https://doi.org/10.1093/annonc/mdu163

4. Mollberg N, Rahbari NN, Koch M, Hartwig W, Hoeger Y, Buchler MW, Weitz J (2011) Arterial resection during pancreatectomy for pancreatic cancer: a systematic review and meta-analysis. Ann Surg 254(6):882–893. https://doi.org/10.1097/SLA.0b013e31823ac299

5. Giovinazzo F, Turri G, Katz MH, Heaton N, Ahmed I (2016) Meta-analysis of benefits of portal-superior mesenteric vein resection in pancreatic resection for ductal adenocarcinoma. Br J Surg 103(3):179–191. https://doi.org/10.1002/bjs.9969

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