Inhibition of P2X7 Receptor Ameliorates Nuclear Factor-Kappa B Mediated Neuroinflammation Induced by Status Epilepticus in Rat Hippocampus
Author:
Funder
National Natural Science Foundation of China
Publisher
Springer Science and Business Media LLC
Subject
Cellular and Molecular Neuroscience,General Medicine
Link
http://link.springer.com/article/10.1007/s12031-017-0968-z/fulltext.html
Reference46 articles.
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3. Auvin S, Shin D, Mazarati A, Sankar R (2010b) Inflammation induced by LPS enhances epileptogenesis in immature rat and may be partially reversed by IL1RA. Epilepsia 51(Suppl 3):34–38. https://doi.org/10.1111/j.1528-1167.2010.02606.x
4. Bernardino L et al (2008) Inflammatory events in hippocampal slice cultures prime neuronal susceptibility to excitotoxic injury: a crucial role of P2X7 receptor-mediated IL-1beta release. J Neurochem 106:271–280. https://doi.org/10.1111/j.1471-4159.2008.05387.x
5. Burnstock G (2008) Purinergic signalling and disorders of the central nervous system. Nat Rev Drug Discov 7:575–590. https://doi.org/10.1038/nrd2605
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