A Novel scFv Anti-Aβ Antibody Reduces Pathological Impairments in APP/PS1 Transgenic Mice via Modulation of Inflammatory Cytokines and Aβ-related Enzymes
Author:
Funder
National Natural Science Foundation of China
Publisher
Springer Science and Business Media LLC
Subject
Cellular and Molecular Neuroscience,General Medicine
Link
http://link.springer.com/article/10.1007/s12031-018-1139-6/fulltext.html
Reference40 articles.
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2. Cattepoel S, Hanenberg M, Kulic L, Nitsch RM (2011) Chronic intranasal treatment with an anti-Abeta(30-42) scFv antibody ameliorates amyloid pathology in a transgenic mouse model of Alzheimer's disease. PLoS One 6:e18296. https://doi.org/10.1371/journal.pone.0018296
3. Cheng L, Yin WJ, Zhang JF, Qi JS (2009) Amyloid beta-protein fragments 25-35 and 31-35 potentiate long-term depression in hippocampal CA1 region of rats in vivo. Synapse 63:206–214. https://doi.org/10.1002/syn.20599
4. Cheng L et al (2017) A novel antibody targeting sequence 31-35 in amyloid beta protein attenuates Alzheimer's disease-related neuronal damage. Hippocampus 27:122–133. https://doi.org/10.1002/hipo.22676
5. Deng J et al (2015) Soluble amyloid precursor protein alpha inhibits tau phosphorylation through modulation of GSK3beta signaling pathway. J Neurochem 135:630–637. https://doi.org/10.1111/jnc.13351
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