Identification of Chromatin Regulatory Factors Related to Immunity and Treatment of Alzheimer’s Disease-Reference-Cited by-同舟云学术

Identification of Chromatin Regulatory Factors Related to Immunity and Treatment of Alzheimer’s Disease

Published:2023-02-24 Issue:2-3 Volume:73 Page:85-94
ISSN:0895-8696
Container-title:Journal of Molecular Neuroscience
language:en
Short-container-title:J Mol Neurosci

Author:

Xiong Fengzhen,Li Chenglong,Wang Qingbo,Geng Xin,Yuan Zhengbo,Li Zefu

Abstract

AbstractAlzheimer’s disease is one of the common neurodegenerative diseases in the elderly, which mainly manifests as progressively severe cognitive impairment, which seriously affects the quality of life of patients. Chromatin regulators have been shown to be associated with a variety of biological processes, and we mainly explore the relationship between chromatin regulators and Alzheimer’s disease. Eight hundred seventy chromatin regulators were collected from previous studies, and data related to Alzheimer’s disease patients were downloaded from the GEO database. Finally, we screened chromatin regulators related to Alzheimer's disease immunity, established prediction models, and screened related drugs and miRNAs. We screened 160 differentially expressed CRs, constructed an interaction network, obtained 10 hub genes, successfully constructed a prediction model based on immune-related 5 CRs, and obtained 520 related drugs and 3 related miRNA, which provided an idea for the treatment of Alzheimer's disease. Our study identified 5 chromatin regulators related to Alzheimer’s disease, which are expected to be new targets for Alzheimer’s disease immunotherapy.

Publisher

Springer Science and Business Media LLC

Subject

Cellular and Molecular Neuroscience,General Medicine

Link

https://link.springer.com/content/pdf/10.1007/s12031-023-02107-0.pdf

Reference43 articles.

1. Adolfsson O, Pihlgren M, Toni N, Varisco Y, Buccarello AL, Antoniello K, Lohmann S, Piorkowska K, Gafner V, Atwal JK, Maloney J, Chen M, Gogineni A, Weimer RM, Mortensen DL, Friesenhahn M, Ho C, Paul R, Pfeifer A, Muhs A, Watts RJ (2012) An effector-reduced anti–amyloid (A) antibody with unique A binding properties promotes neuroprotection and glial engulfment of A. J Neurosci 32(28):9677–9689. https://doi.org/10.1523/JNEUROSCI.4742-11.2012

2. Bohrmann B, Baumann K, Benz J, Gerber F, Huber W, Knoflach F, Messer J, Oroszlan K, Rauchenberger R, Richter WF, Rothe C, Urban M, Bardroff M, Winter M, Nordstedt C, Loetscher H (2012) Gantenerumab: a novel human anti-Aβ antibody demonstrates sustained cerebral amyloid-β binding and elicits cell-mediated removal of human amyloid-β. J Alzheimers Dis 28(1):49–69. https://doi.org/10.3233/JAD-2011-110977

3. Chang C, Huang C, Chang S, Wu C, Chen H, Luo C, Yip H (2021) CHD4 as an important mediator in regulating the malignant behaviors of colorectal cancer. Int J Biol Sci 17(7):1660–1670. https://doi.org/10.7150/ijbs.56976

4. Gao S, Qi X, Li J, Sang L (2017) Upregulated KAT7 in synovial fibroblasts promotes Th17 cell differentiation and infiltration in rheumatoid arthritis. Biochem Biophys Res Commun 489(2):235–241. https://doi.org/10.1016/j.bbrc.2017.05.143

5. Gao Y, Zhao H, Mu L (2021) LncRNA-KAT7 negatively regulates miR-10a through an epigenetic pathway to participate in nonsmall cell lung cancer [Journal Article]. Cancer Biother Radiopharm 36(5):441–445. https://doi.org/10.1089/cbr.2019.3228

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