Author:
Houwing Danielle J.,Esquivel-Franco Diana C.,Ramsteijn Anouschka S.,Schuttel Kirsten,Struik Eline L.,Arling Chantal,de Boer Sietse F.,Olivier Jocelien D. A.
Abstract
Abstract
Rationale
Many depressed women continue antidepressant treatment during pregnancy. Selective serotonin reuptake inhibitor (SSRI) treatment during pregnancy increases the risk for abnormal social development of the child, including increased aggressive or defiant behavior, with unknown effects on sexual behavior.
Objectives
Our aim was to investigate the effects of perinatal SSRI treatment and maternal depression, both separately and combined, on aggressive and sexual behavior in male rat offspring.
Methods
Heterozygous serotonin transporter (SERT± ) knockout dams exposed to early life stress (ELSD) were used as an animal model of maternal depression. Early life stress consisted of separating litters from their mother for 6 h a day on postnatal day (PND)2–15, resulting in a depressive-like phenotype in adulthood. Depressive-like dams were treated with fluoxetine (FLX, 10 mg/kg) or vehicle throughout pregnancy and lactation (gestational day 1 until PND 21). Male offspring were tested for aggressive and sexual behavior in adulthood. As lifelong reductions in SERT expression are known to alter behavioral outcome, offspring with normal (SERT+/+) and reduced (SERT± ) SERT expression were assessed.
Results
Perinatal FLX treatment reduced offensive behavior and the number of animals attacking and increased the latency to attack, especially in SERT+/+ offspring. Perinatal FLX treatment reduced the mounting frequency in SERT+/+ offspring. ELSD increased offensive behavior, without affecting sexual behavior in SERT± offspring.
Conclusions
Overall, our research demonstrates that perinatal FLX treatment and ELSD have opposite effects on aggressive behavior, with little impact on sexual behavior of male offspring.
Funder
Brain and Behavior Research Foundation
H2020 Marie Skłodowska-Curie Actions
Publisher
Springer Science and Business Media LLC
Reference65 articles.
1. Anderson DJ (2012) Optogenetics, sex, and violence in the brain: implications for psychiatry. BPS 71:1081–1089. https://doi.org/10.1016/j.biopsych.2011.11.012
2. Azmitia EC (2001) Modern views on an ancient chemical: serotonin effects on cell proliferation, maturation, and apoptosis. Brain Res Bull 56:413–424. https://doi.org/10.1016/S0361-9230(01)00614-1
3. Brown HK, Hussain-Shamsy N, Lunsky Y, Dennis CLE, Vigod SN (2017) The association between antenatal exposure to selective serotonin reuptake inhibitors and autism: a systematic review and meta-analysis. J Clin Psychiatry 78:e48–e58. https://doi.org/10.4088/JCP.15r10194
4. Brummelte S, Galea LAM (2010) Depression during pregnancy and postpartum: contribution of stress and ovarian hormones. Prog Neuropsychopharmacol Biol Psychiatry 34:766–776. https://doi.org/10.1016/j.pnpbp.2009.09.006
5. Cagiano R, Flace P, Bera I, Maries L, Cioca G, Sabatini R, Benagiano V, Auteri P, Marzullo A, Vermesan D, Stefanelli R, Ambrosi G (2008) Neurofunctional effects in rats prenatally exposed to fluoxetine. Eur Rev Med Pharmacol Sci 12:137–148
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