Pharmacological profile of a 17β-heteroaryl-substituted neuroactive steroid

Author:

Hogenkamp Derk J.,Tran Minhtam B.,Yoshimura Ryan F.,Johnstone Timothy B.,Kanner Richard,Gee Kelvin W.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology

Reference16 articles.

1. Bialer M, Johannessen SI, Levy RH, Perucca E, Tomson T, White HS (2013) Progress report on new antiepileptic drugs: a summary of the Eleventh Eilat Conference (EILAT XI). Epilepsy Res 103:2–30

2. Carter RB, Wood PL, Wieland S, Hawkinson JE, Belelli D, Lambert JJ, White HS, Wolf HH, Mirsadeghi S, Tahir SH, Bolger MB, Lan NC, Gee KW (1997) Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3α-hydroxy-3β-methyl-5α-pregnan-20 one), a selective, high-affinity, steroid modulator of the γ-aminobutyric acidA receptor. J Pharmacol Exp Ther 280:1284–1295

3. Gee KW, Tran MB, Hogenkamp DJ, Johnstone TB, Bagnera RE, Yoshimura RF, Huang J-C, Belluzzi JD, Whittemore ER (2010) Limiting activity at β1-subunit-containing GABAA receptor subtypes reduces ataxia. J Pharmacol Exp Ther 332:1040–1053

4. Hawkinson JE, Acosta-Burruel M, Yang KC, Hogenkamp DJ, Chen JS, Lan NC, Drewe JA, Whittemore ER, Woodward RM, Carter RB, Upasani RB (1998) Substituted 3β-phenylethynyl derivatives of 3α-hydroxy-5α-pregnan-20-one: remarkably potent neuroactive steroid modulators of γ-aminobutyric acidA receptors. J Pharmacol Exp Ther 287:198–207

5. Hogenkamp DJ (2013) Novel 17β-heteraryl-substituted steroids as modulators of GABAA receptors. International Published Application WO 2013/019711 A2, Feb. 7, 2013

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