Phase I/II clinical trial of didemnin B in non-small-cell lung cancer: neuromuscular toxicity is dose-limiting

Author:

Shin Dong M.,Holoye Paul Y.,Murphy William K.,Forman Arthur,Papasozomenos Sozos C.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference13 articles.

1. Abbruzzese J, Ajani J, Blackburn R, Faintuch J, Patt Y, Levin B (1988) Phase II study of didemnin B in advanced colorectal cancer. Proc Am Assoc Cancer Res 29: A805

2. Crampton SL, Adams EG, Kuentzel SL, Li LH, Badiner G, Bhuyan BK (1984) Biochemical and cellular effects of didemnins A and B. Cancer Res 44: 1796

3. Dorr FA, Kuhn JG, Phillips J, Von Hoff DD (1988) Phase I clinical and pharmacokinetic investigation of didemnin B, a cyclic pepsipeptide. Eur J Cancer Clin Oncol 24: 1699

4. Houssain MB, Van De D, Weinheimer AJ (1988) Crystal and molecular structure of didemnin B, and antiviral and cytotoxic depsipeptide. Proc Natl Acad Sci USA 85: 4118

5. Jiang TL, Liu RH, Salmon SE (1983) Antitumor activity of didemnin B in the human tumor stem cell assay. Cancer Chemother Pharmacol 11: 1

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