Pharmacokinetic study of methotrexate, folinic acid and their serum metabolites in children treated with high-dose methotrexate and leucovorin rescue

Author:

Wolfrom C.,Hepp R.,Hartmann R.,Breithaupt H.,Henze G.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,General Medicine

Reference61 articles.

1. Borsi J, Moe PJ (1987) A comparative study on the pharmacokinetics of methotrexate in a dose range of 0.5 to 33.6 g/sqm in children with acute lymphoblastic leukemia. Cancer 60: 5?13

2. Bore P, Bruno R, Lena N, Favre R, Cano JP (1987) Methotrexate and 7-hydroxy-methotrexate pharmacokinetics following intravenous bolus administration and high-dose infusion of methotrexate. Eur J Cancer Clin Oncol 23: 1385?1390

3. Taguchi H (1986) Metabolism of leucovorin following oral and parenteral administration. In: Kimura K, Wang YM (ed) Methotrexate in cancer therapy. Raven Press, New York

4. Straw JA, Szapary D, Wynn WT (1984) Pharmacokinetics of the diastereoisomers of leucovorin after intravenous and oral administration to normal subjects. Cancer Res 44: 3114?3119

5. Periti P (1983) Single dose folate pharmacokinetics in normal adults. In: Djerassi J, Baumgartner G (ed.). Proceedings of the 13th International Congress of Chemotherapy, Vienna Aug 28th?Sept 2nd 1983. Symposion advances in high dose methotrexate-citrovorum rescue for clinical practice on cancer chemotherapy. SY90, Part 217. Spitzky KH, Karrer K, pp 28?31

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