Prophylaxis and Treatment of Invasive Aspergillosis: Who and How of Prophylaxis, Treatment, and New Therapies

Author:

Vergidis Paschalis,Denning David W.

Publisher

Springer Science and Business Media LLC

Subject

General Medicine

Reference94 articles.

1. • Ethier MC, Science M, Beyene J, Briel M, Lehrnbecher T, Sung L. Mould-active compared with fluconazole prophylaxis to prevent invasive fungal diseases in cancer patients receiving chemotherapy or haematopoietic stem-cell transplantation: a systematic review and meta-analysis of randomised controlled trials. Br J Cancer. 2012;106(10):1626–37. https://doi.org/10.1038/bjc.2012.147This meta-analysis showed that mold-active prophylaxis significantly reduced the rate of invasive aspergillosis compared to fluconazole in cancer patients receiving chemotherapy or hematopoietic stem cell transplant.

2. Maertens JA, Girmenia C, Bruggemann RJ, Duarte RF, Kibbler CC, Ljungman P, et al. European guidelines for primary antifungal prophylaxis in adult haematology patients: summary of the updated recommendations from the European Conference on Infections in Leukaemia. J Antimicrob Chemother. 2018;73(12):3221–30. https://doi.org/10.1093/jac/dky286.

3. Chen CY, Sheng WH, Tien FM, Lee PC, Huang SY, Tang JL, et al. Clinical characteristics and treatment outcomes of pulmonary invasive fungal infection among adult patients with hematological malignancy in a medical centre in Taiwan, 2008–2013. J Microbiol Immunol Infect. 2018. https://doi.org/10.1016/j.jmii.2018.01.002.

4. Cornely OA, Maertens J, Winston DJ, Perfect J, Ullmann AJ, Walsh TJ, et al. Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia. N Engl J Med. 2007;356(4):348–59. https://doi.org/10.1056/NEJMoa061094.

5. Duarte RF, Lopez-Jimenez J, Cornely OA, Laverdiere M, Helfgott D, Haider S, et al. Phase 1b study of new posaconazole tablet for prevention of invasive fungal infections in high-risk patients with neutropenia. Antimicrob Agents Chemother. 2014;58(10):5758–65. https://doi.org/10.1128/AAC.03050-14.

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