Economical Voltammetric Sensor for Sensitive Rapid Determination of Ondansetron in the Presence of Opioid Antagonist Naltrexone

Abstract

AbstractThe electrochemical actions of ondansetron (OND) were investigated on the modified electrode with Polyvinyl Pyrollidone (PVP) and multi-walled carbon nanotube (MWCNTs). The oxidation peak current was enhanced to be doubled when compared to the bare electrode as a result of the synergistic effect of nanomaterial and cation-exchange polymer on the electron transfer rate. Following optimization of the experimental conditions, the Square Wave Voltammograms (SWV) method was employed to determine ondansetron in pharmaceutical formulations. Moreover, the modified electrode MWCNTs/PVP/CPE displayed high selectivity in the voltammetric measurements of ondansetron and co-administrated opioid antagonist drug naltrexone (NAL) with strong potential separation (422 mV). The response peak currents had a linear relationship with drug concentration in the range of (2.00–200.0 nmolL−1) with detection limits 430 pmolL−1 and 456 pmolL−1 for ondansetron and naltrexone, respectively. The electrode was successfully used to detect both medications electrochemically in human plasma samples. Graphical abstract