Sirolimus (rapamycin) inhibits mitogen-induced stimulation of protein synthesis in primary lymphocytes
Author:
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology,Immunology
Link
http://link.springer.com/content/pdf/10.1007/BF01778320.pdf
Reference7 articles.
1. Sehgal SN, Bansbach CC. Rapamycin: in vitro profile of a new immunosuppressive macrolide. Ann of NY Academy Sciences 1993;685:58–67.
2. Chung J, Kuo CJ, Crabtree GR, Blenis J. Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Cell 1992;69:1227–36.
3. Kuo CJ, Chung J, Florentino DF, Flanagan WM, Blenis J, Crabtree GR. Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature 1992;358:70–3.
4. Price DJ, Grove JR, Calvo V, Avruch J, Bierer BE. Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase. Science 1992;257:973–7.
5. Terada N, Lucas JJ, Szepesi A, Franklin RA, Takase K, Gelfand EW. Rapamycin inhibits the phosphorylation of p70 S6 kinase in IL-2 and mitogen-activated human T cells. Biochem Biophys Res Commun 1992;186:1315–21.
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