Production of a mouse monoclonal IgM antibody that targets the carbohydrate Thomsen-nouveau cancer antigen resulting in in vivo and in vitro tumor killing

Author:

Trabbic Kevin R.,Kleski Kristopher A.,Shi Mengchao,Bourgault Jean-Paul,Prendergast Jillian M.,Dransfield Daniel T.,Andreana Peter R.ORCID

Funder

National Cancer Institute

U.S. Department of Health and Human Services

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology,Immunology,Immunology and Allergy

Reference46 articles.

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2. O’Cearbhaill RE, Ragupathi G, Zhu J, Wan Q, Mironov S, Yang G, Spassova MK, Iasonos A, Kravetz S, Ouerfelli O, Spriggs DR, Danishefsky SJ, Sabbatini PJ (2016) A phase I study of unimolecular pentavalent (Globo-H-GM2-STn-TF-Tn) immunization of patients with epithelial ovarian, fallopian tube, or peritoneal cancer in first remission. Cancers (Basel). https://doi.org/10.3390/cancers8040046

3. Laubreton D, Bay S, Sedlik C, Artaud C, Ganneau C, Deriaud E, Viel S, Puaux AL, Amigorena S, Gerard C, Lo-Man R, Leclerc C (2016) The fully synthetic MAG-Tn3 therapeutic vaccine containing the tetanus toxoid-derived TT830-844 universal epitope provides anti-tumor immunity. Cancer Immunol Immunother 65(3):315–325. https://doi.org/10.1007/s00262-016-1802-0

4. Scheid E, Major P, Bergeron A, Finn OJ, Salter RD, Eady R, Yassine-Diab B, Favre D, Peretz Y, Landry C, Hotte S, Mukherjee SD, Dekaban GA, Fink C, Foster PJ, Gaudet J, Gariepy J, Sekaly RP, Lacombe L, Fradet Y, Foley R (2016) Tn-MUC1 DC vaccination of rhesus macaques and a phase I/II trial in patients with nonmetastatic castrate-resistant prostate cancer. Cancer Immunol Res 4(10):881–892. https://doi.org/10.1158/2326-6066.cir-15-0189

5. Gilewski T, Ragupathi G, Bhuta S, Williams LJ, Musselli C, Zhang XF, Bornmann WG, Spassova M, Bencsath KP, Panageas KS, Chin J, Hudis CA, Norton L, Houghton AN, Livingston PO, Danishefsky SJ (2001) Immunization of metastatic breast cancer patients with a fully synthetic Globo H conjugate: a phase I trial. Proc Natl Acad Sci USA 98(6):3270–3275. https://doi.org/10.1073/pnas.051626298

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