Safety evaluation of DT388IL3, a diphtheria toxin/interleukin 3 fusion protein, in the cynomolgus monkey-Reference-Cited by-同舟云学术

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Safety evaluation of DT388IL3, a diphtheria toxin/interleukin 3 fusion protein, in the cynomolgus monkey

Published:2004-12-22 Issue:8 Volume:54 Page:799-806
ISSN:0340-7004
Container-title:Cancer Immunology, Immunotherapy
language:en
Short-container-title:Cancer Immunol Immunother

Author:

Cohen Kimberley A.,Liu Tie Fu,Cline J. Mark.,Wagner Janice D.,Hall Philip D.,Frankel Arthur E.

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology,Immunology,Immunology and Allergy

Link

http://link.springer.com/content/pdf/10.1007/s00262-004-0643-4.pdf

Reference32 articles.

1. Ailles LE, Gerhard B, Hogge DE (1997) Detection and characterization of primitive malignant and normal progenitors in patients with acute myelogenous leukemia using long-term coculture with supportive feeder layers and cytokines. Blood 90:2555–2564

2. Alexander RL, Kucera GL, Klein B, Frankel AE (2000) In vitro interleukin-3 binding to leukemia cells predicts cytotoxicity of a diphtheria toxin/IL-3 fusion protein. Bioconjug Chem 11:564–568

3. Alexander RL, Ramage J, Kucera GL, Caligiuri MA, Frankel AE (2001) High affinity interleukin-3 receptor expression on blasts from patients with acute myelogenous leukemia correlates with cytotoxicity of a diphtheria toxin/IL-3 fusion protein. Leuk Res 25:875–881

4. Black JH, McCubrey JA, Willingham MC, Ramage J, Hogge DE, Frankel AE (2003) Diphtheria toxin-interleukin-3 fusion protein (DT(388)IL3) prolongs disease-free survival of leukemic immunocompromised mice. Leukemia 17:155–159

5. Bodley JW, Dunlop PC, VanNess BG (1984) Diphthamide in elongation factor 2: ADP-ribosylation, purification, and properties. Methods Enzymol 106:378–387

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