Blockade of IL-1α and IL-1β signaling by the anti-IL1RAP antibody nadunolimab (CAN04) mediates synergistic anti-tumor efficacy with chemotherapy-Reference-Cited by-同舟云学术

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Blockade of IL-1α and IL-1β signaling by the anti-IL1RAP antibody nadunolimab (CAN04) mediates synergistic anti-tumor efficacy with chemotherapy

Published:2022-08-29 Issue:3 Volume:72 Page:667-678
ISSN:0340-7004
Container-title:Cancer Immunology, Immunotherapy
language:en
Short-container-title:Cancer Immunol Immunother

Author:

Rydberg Millrud Camilla,Deronic Adnan,Grönberg Caitríona,Jaensson Gyllenbäck Elin,von Wachenfeldt Karin,Forsberg Göran,Liberg David

Funder

Cantargia AB

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology,Immunology,Immunology and Allergy

Link

https://link.springer.com/content/pdf/10.1007/s00262-022-03277-3.pdf

Reference39 articles.

1. Dinarello CA (2009) Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol 27:519–550. https://doi.org/10.1146/annurev.immunol.021908.132612

2. Korherr C, Hofmeister R, Wesche H, Falk W (1997) A critical role for interleukin-1 receptor accessory protein in interleukin-1 signaling. Eur J Immunol 27:262–267. https://doi.org/10.1002/eji.1830270139

3. Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU (1997) The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases). J Biol Chem 272:7727–7731. https://doi.org/10.1074/jbc.272.12.7727

4. Kim B, Lee Y, Kim E, Kwak A, Ryoo S, Bae SH, Azam T, Kim S, Dinarello CA (2013) The interleukin-1alpha precursor is biologically active and is likely a key alarmin in the IL-1 family of cytokines. Front Immunol 4:391. https://doi.org/10.3389/fimmu.2013.00391

5. Howard AD, Kostura MJ, Thornberry N et al (1991) IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha. J Immunol 147:2964–2969

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