Use of CD40L immunoconjugates to overcome the defective immune response to vaccines for infections and cancer in the aged-Reference-Cited by-同舟云学术

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Use of CD40L immunoconjugates to overcome the defective immune response to vaccines for infections and cancer in the aged

Published:2009-05-15 Issue:12 Volume:58 Page:1949-1957
ISSN:0340-7004
Container-title:Cancer Immunology, Immunotherapy
language:en
Short-container-title:Cancer Immunol Immunother

Author:

Tang Yu Cheng,Thoman Marilyn,Linton Phyllis-Jean,Deisseroth Albert

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology,Immunology,Immunology and Allergy

Link

http://link.springer.com/content/pdf/10.1007/s00262-009-0718-3.pdf

Reference39 articles.

1. Castle SC (2000) Clinical relevance of age-related immune dysfunction. Clin Infect Dis 31:578

2. Ortqvist A, Granath F, Askling J, Hedlund J (2007) Influenza vaccination and mortality: prospective cohort study of the elderly in a large geographical area. Eur Respir J 30:414–422

3. Saurwein-Teissl M, Lung TL, Marx F, Gschosser C, Asch E, Lasko I, Parson W, Bock G, Schnoitzer D, Trannoy E et al (2002) Lack of antibody production following immunization in old age: association with CD8+ CD28− T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines. J Immunol 168:5893

4. Haynes L, Eaton SM, Burns EM, Randall TD, Swain SL (2003) CD4 T cell memory derived from young naïve cells functions well into old age, but memory generated from aged naïve cells functions poorly. Proc Natl Acad Sci USA 100:15053–15058

5. Jefferson T et al (2005) Efficacy and effect of influenza vaccines in the elderly. Lancet 264:1165–1174

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