Prostaglandin E2 (PGE2) suppresses natural killer cell function primarily through the PGE2 receptor EP4
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology,Immunology,Immunology and Allergy
Link
http://link.springer.com/content/pdf/10.1007/s00262-011-1064-9.pdf
Reference21 articles.
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2. Su Y, Jackson E, Gorelik E (2010) Receptor desensititzation and blockade of the suppressive effects of prostaglandin E2 and adenosine on the cytotoxic activity of human melanoma-infiltrating T lymphocytes. Cancer Immunol Immunother [Epub ahead of print]
3. Kundu N, Ma X, Holt D, Goloubeva O, Ostrand-Rosenberg S, Fulton A (2009) Antagonism of the prostaglandin E receptor EP4 inhibits metastasis and enhances NK function. Breast Cancer Res Treat 117:235–242
4. Kundu N, Walser T, Ma X, Fulton A (2005) Cyclooxygenase inhibitors modulate NK activities that control metastatic disease. Cancer Immunol Immunother 54:981–987
5. Maghazachi A (2003) G protein-coupled receptors in natural killer cells. J Leukoc Biol 74:16–24
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